Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3709372..3709964 Replicon chromosome
Accession NZ_CP088000
Organism Stenotrophomonas rhizophila strain Bl2-2

Toxin (Protein)


Gene name graT Uniprot ID A0A1B2N862
Locus tag LQE85_RS16985 Protein ID WP_068854073.1
Coordinates 3709686..3709964 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LQE85_RS16980 Protein ID WP_083214286.1
Coordinates 3709372..3709674 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQE85_RS16960 (LQE85_16960) 3704797..3705984 + 1188 WP_249833141.1 pyridoxal phosphate-dependent aminotransferase -
LQE85_RS16965 (LQE85_16965) 3706120..3708213 - 2094 WP_249833142.1 prolyl oligopeptidase family serine peptidase -
LQE85_RS16970 (LQE85_16970) 3708248..3708604 - 357 WP_093533995.1 hypothetical protein -
LQE85_RS16975 (LQE85_16975) 3708769..3709371 + 603 WP_068854071.1 lipocalin family protein -
LQE85_RS16980 (LQE85_16980) 3709372..3709674 - 303 WP_083214286.1 HigA family addiction module antitoxin Antitoxin
LQE85_RS16985 (LQE85_16985) 3709686..3709964 - 279 WP_068854073.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LQE85_RS16990 (LQE85_16990) 3710097..3710786 - 690 WP_249833143.1 methionine ABC transporter permease -
LQE85_RS16995 (LQE85_16995) 3710783..3711790 - 1008 WP_249834390.1 methionine ABC transporter ATP-binding protein -
LQE85_RS17000 (LQE85_17000) 3711923..3712819 - 897 WP_095362990.1 DMT family transporter -
LQE85_RS17005 (LQE85_17005) 3712899..3713381 + 483 WP_249833144.1 YajQ family cyclic di-GMP-binding protein -
LQE85_RS17010 (LQE85_17010) 3713388..3713981 + 594 WP_249833145.1 DUF1415 domain-containing protein -
LQE85_RS17015 (LQE85_17015) 3713972..3714775 + 804 WP_249833146.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(24-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(8-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10759.44 Da        Isoelectric Point: 10.3985

>T226550 WP_068854073.1 NZ_CP088000:c3709964-3709686 [Stenotrophomonas rhizophila]
MIQSFRCRHTLALFEGRCPRRFRSIQAVAERKLQMLDAAQTLQFLRSPPGNRLEALAGERRGQFSIRINVQWRVCFTWTD
AGPCHVEIVDYH

Download         Length: 279 bp

>T226550 NZ_CP122511:c12532-12380 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCGTCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11069.73 Da        Isoelectric Point: 8.7939

>AT226550 WP_083214286.1 NZ_CP088000:c3709674-3709372 [Stenotrophomonas rhizophila]
MSRAANKLRAIHPGEILREEFMAPLELSINALARALDVPATRLHAIVHETRGVTADTAARLARHFGGDAASWLALQAEYD
LKTLSTWQDIERRVMPRVAA

Download         Length: 303 bp

>AT226550 NZ_CP122511:12584-12644 [Escherichia coli]
GAGGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B2N862

Antitoxin

Source ID Structure

References