Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 3337417..3337933 Replicon chromosome
Accession NZ_CP087994
Organism Acetobacterium wieringae strain Y

Toxin (Protein)


Gene name yoeB Uniprot ID A0A1F2PKZ6
Locus tag LNN31_RS15650 Protein ID WP_070370467.1
Coordinates 3337417..3337677 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A1F2PJ82
Locus tag LNN31_RS15655 Protein ID WP_070370466.1
Coordinates 3337670..3337933 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LNN31_RS15640 (LNN31_15600) 3336039..3336665 - 627 WP_228881270.1 hypothetical protein -
LNN31_RS15645 (LNN31_15605) 3336932..3337357 + 426 WP_228881267.1 pyridoxamine 5'-phosphate oxidase family protein -
LNN31_RS15650 (LNN31_15610) 3337417..3337677 - 261 WP_070370467.1 Txe/YoeB family addiction module toxin Toxin
LNN31_RS15655 (LNN31_15615) 3337670..3337933 - 264 WP_070370466.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
LNN31_RS15660 (LNN31_15620) 3338056..3339327 - 1272 WP_228881264.1 nickel-dependent lactate racemase -
LNN31_RS15665 (LNN31_15625) 3339562..3341103 - 1542 WP_148638467.1 L-lactate permease -
LNN31_RS15670 (LNN31_15630) 3341112..3342512 - 1401 WP_070370463.1 FAD-binding oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10394.86 Da        Isoelectric Point: 9.2193

>T226531 WP_070370467.1 NZ_CP087994:c3337677-3337417 [Acetobacterium wieringae]
MSNLTFSDKGWEDYLYWQLTDKKMLRRINELLKDIQRNGYTGIGKPEPLKYRKAWSRRIDLEHRLVYALDEDGNIYILSL
KGHYQD

Download         Length: 261 bp

>T226531 NZ_CP122507:2294168-2294344 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10047.49 Da        Isoelectric Point: 4.6952

>AT226531 WP_070370466.1 NZ_CP087994:c3337933-3337670 [Acetobacterium wieringae]
MLAVNYSTIRSKLKDYCDKATDENETVIVTRKDEKNVVIMSLDKYNEIMRTARNAEYLDMIDRSIEQVRQGKVVVKSMAE
LEALADE

Download         Length: 264 bp

>AT226531 NZ_CP122507:2294390-2294806 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1F2PKZ6

Antitoxin

Source ID Structure
AlphaFold DB A0A1F2PJ82

References