Detailed information of TA system TA022650

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/Tad-HTH_37
• Location: 73701..74304
• Replicon: plasmid p3ABAYE
• Accession: NC_010404
• Organism: Acinetobacter baumannii AYE

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: ABAYE_RS00440
• Protein ID: WP_000288004.1
• Coordinates: 73701..74030 (+)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: ABAYE_RS00445
• Protein ID: WP_001258993.1
• Coordinates: 74017..74304 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ABAYE_RS00400	69503..69831	+	329	Protein_62	DUF4236 domain-containing protein	-
ABAYE_RS00405	70073..70585	-	513	WP_000464612.1	Fic family protein	-
ABAYE_RS00410	70588..70773	-	186	WP_000755724.1	hypothetical protein	-
ABAYE_RS00415	70940..71872	+	933	WP_000743263.1	IS5 family transposase	-
ABAYE_RS00420	72003..72200	-	198	WP_025464206.1	hypothetical protein	-
ABAYE_RS00425	72293..72511	-	219	WP_000994925.1	hypothetical protein	-
ABAYE_RS00430	72568..73170	-	603	WP_000096286.1	hypothetical protein	-
ABAYE_RS00435	73377..73646	+	270	WP_000453245.1	transcriptional regulator	-
ABAYE_RS00440	73701..74030	+	330	WP_000288004.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ABAYE_RS00445	74017..74304	+	288	WP_001258993.1	helix-turn-helix domain-containing protein	Antitoxin
ABAYE_RS00450	74341..74529	-	189	WP_000340067.1	hypothetical protein	-
ABAYE_RS19525	74952..75275	-	324	Protein_73	DUF4236 domain-containing protein	-
ABAYE_RS19530	75284..75460	-	177	WP_002120129.1	hypothetical protein	-
ABAYE_RS20500	75532..75855	-	324	WP_005804845.1	hypothetical protein	-
ABAYE_RS00460	76210..76719	-	510	Protein_76	terminase	-
ABAYE_RS19540	76703..77226	-	524	Protein_77	DUF2280 domain-containing protein	-
ABAYE_RS00475	77317..77958	-	642	WP_000372120.1	hypothetical protein	-
ABAYE_RS00480	77927..78388	-	462	WP_000378528.1	hypothetical protein	-
ABAYE_RS00485	78449..78904	-	456	WP_001136766.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..94413	94413
	-	flank	IS/Tn	-	-	70940..71872	932

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-102)

Antitoxin

• Cro/C1-type helix-turn-helix domain (38-90)

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 12571.69 Da
• Isoelectric Point: 8.8102

>T22650 WP_000288004.1 NC_010404:73701-74030 [Acinetobacter baumannii AYE]
MYTIEYYSEDVQDEILTLPDGLLARYFNLTDRMVIYGANLGEPHTLPMSKGLFELRLKSQEGIARVMYCTLVGKRIVMLH
SFVKKTQKTPKQDLNLALDRMKEVKNANT

Nucleotide

• Length: 330 bp

>T22650 NC_010404:73701-74030 [Acinetobacter baumannii AYE]
ATGTATACAATTGAATATTACAGCGAAGACGTTCAGGATGAGATTCTTACATTACCTGATGGTCTTTTGGCTCGATATTT
TAACTTAACTGACCGTATGGTGATTTACGGCGCAAACTTAGGAGAACCTCACACATTACCAATGAGTAAAGGACTATTTG
AGTTGCGCTTAAAATCTCAAGAAGGTATTGCTCGTGTTATGTATTGCACACTAGTCGGTAAACGCATTGTAATGCTCCAT
AGTTTTGTTAAGAAAACCCAAAAAACACCTAAGCAAGATCTAAACCTAGCACTTGACCGCATGAAAGAGGTGAAAAATGC
GAACACATGA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10565.30 Da
• Isoelectric Point: 10.1453

>AT22650 WP_001258993.1 NC_010404:74017-74304 [Acinetobacter baumannii AYE]
MRTHEEMKALALSRSAVRTEYERIEREEMPLLDMVLTARRDAGLSQAQIAERMGTSVPAVSRLEKALITGKPSPSIATLQ
KYAAAIGKHVEVRFV

Nucleotide

• Length: 288 bp

>AT22650 NC_010404:74017-74304 [Acinetobacter baumannii AYE]
ATGCGAACACATGAAGAAATGAAAGCACTTGCATTATCTCGTTCAGCAGTGCGTACCGAATACGAACGAATTGAACGTGA
AGAAATGCCCCTGCTCGATATGGTACTTACTGCACGTCGAGATGCAGGTCTATCCCAAGCGCAAATCGCGGAACGCATGG
GAACAAGTGTACCTGCCGTTTCACGGCTAGAAAAAGCATTGATCACAGGCAAACCATCACCATCTATTGCCACATTGCAA
AAATATGCTGCGGCAATTGGTAAACATGTTGAAGTGCGTTTTGTCTAA