Detailed information of TA system TA022649

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 40251..40902
• Replicon: plasmid p3ABAYE
• Accession: NC_010404
• Organism: Acinetobacter baumannii AYE

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: ABAYE_RS00295
• Protein ID: WP_000269910.1
• Coordinates: 40251..40559 (+)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: ABAYE_RS00300
• Protein ID: WP_001140619.1
• Coordinates: 40600..40902 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ABAYE_RS00270	35876..36394	+	519	WP_000447196.1	sel1 repeat family protein	-
ABAYE_RS00275	36526..37038	+	513	WP_001089570.1	SMI1/KNR4 family protein	-
ABAYE_RS00280	37246..38148	+	903	WP_000466974.1	hypothetical protein	-
ABAYE_RS00285	38405..38650	+	246	WP_000246757.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
ABAYE_RS00290	38640..38933	+	294	WP_000221360.1	type II toxin-antitoxin system RelE/ParE family toxin	-
ABAYE_RS19510	39120..39236	+	117	Protein_41	transposase	-
ABAYE_RS00295	40251..40559	+	309	WP_000269910.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ABAYE_RS00300	40600..40902	+	303	WP_001140619.1	XRE family transcriptional regulator	Antitoxin
ABAYE_RS00305	40895..41104	+	210	WP_000069470.1	hypothetical protein	-
ABAYE_RS00310	41214..41441	-	228	WP_000555567.1	hypothetical protein	-
ABAYE_RS00315	42207..42510	-	304	Protein_46	helix-turn-helix transcriptional regulator	-
ABAYE_RS00320	42503..42859	-	357	WP_000269908.1	type II toxin-antitoxin system RelE/ParE family toxin	-
ABAYE_RS00325	43417..44100	+	684	WP_000478902.1	hypothetical protein	-
ABAYE_RS00330	44305..44833	+	529	Protein_49	IS3 family transposase	-
ABAYE_RS00335	45076..45396	+	321	WP_001081101.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..94413	94413

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-102)

Antitoxin

• HigA2-like, helix-turn-helix domain (13-89)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 11742.64 Da
• Isoelectric Point: 9.0002

>T22649 WP_000269910.1 NC_010404:40251-40559 [Acinetobacter baumannii AYE]
MWTVITTDLFNEWLVQQDQSTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKGGKKRFYKEMLDIAD

Nucleotide

• Length: 309 bp

>T22649 NC_010404:40251-40559 [Acinetobacter baumannii AYE]
ATGTGGACAGTCATTACAACGGATCTGTTTAACGAATGGCTTGTACAGCAAGATCAATCTACACAAGAGAAAGTACTCGC
AGCGTTGGTCGTTCTACAGCAACAGGGACCAAGTTTAGGACGTCCTTTAGTAGATACCGTCTATGACTCCAAATTTACCA
ATATGAAAGAGCTACGTGTTCAGCATCGAGGTAAACCACTGAGAGCCTTTTTCGCGTTTGATCCTTTACGACAAGCTATT
GTGCTGTGTATCGGTGATAAAGGCGGTAAAAAGCGTTTTTATAAAGAGATGTTAGATATTGCCGATTAG

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11206.01 Da
• Isoelectric Point: 6.7282

>AT22649 WP_001140619.1 NC_010404:40600-40902 [Acinetobacter baumannii AYE]
MAKTLQELLANRSPESQARIQQMADELLLETQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Nucleotide

• Length: 303 bp

>AT22649 NC_010404:40600-40902 [Acinetobacter baumannii AYE]
ATGGCTAAGACCCTACAAGAATTATTGGCTAATCGCTCTCCAGAGAGTCAAGCTCGTATTCAACAAATGGCGGATGAATT
ATTGTTGGAAACTCAGCTTCACCTTATTCGTGAAGAGTTGGAGATTTCTCAAAAAGAACTGGCTGCAACCCTTGGAATCA
AACAGCCTTCATTGTCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACGATGAAAAAGTATGTCGAAGCAATG
GGCGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACATATAGGATTCAATGTCTAA