Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2114466..2115082 Replicon chromosome
Accession NZ_CP087952
Organism Desulfosarcina sp. BuS5

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag BuS5_RS10390 Protein ID WP_027353236.1
Coordinates 2114466..2114762 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag BuS5_RS10395 Protein ID WP_035264614.1
Coordinates 2114771..2115082 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BuS5_RS10365 (BuS5_02101) 2109843..2110073 - 231 WP_198012332.1 4Fe-4S binding protein -
BuS5_RS10370 (BuS5_02102) 2110215..2110901 - 687 WP_274427644.1 IS1 family transposase -
BuS5_RS10375 (BuS5_02103) 2111306..2113144 + 1839 WP_051375227.1 DUF3141 domain-containing protein -
BuS5_RS10380 (BuS5_02104) 2113591..2114070 - 480 WP_274427645.1 hypothetical protein -
BuS5_RS10385 2114180..2114410 + 231 WP_027353235.1 hypothetical protein -
BuS5_RS10390 (BuS5_02105) 2114466..2114762 + 297 WP_027353236.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BuS5_RS10395 (BuS5_02106) 2114771..2115082 + 312 WP_035264614.1 HigA family addiction module antitoxin Antitoxin
BuS5_RS10400 2115278..2115337 - 60 Protein_2052 hypothetical protein -
BuS5_RS10405 2115413..2115532 - 120 WP_274427646.1 type II toxin-antitoxin system YoeB family toxin -
BuS5_RS10410 2115529..2115663 - 135 WP_232223021.1 hypothetical protein -
BuS5_RS10415 (BuS5_02110) 2116158..2117480 - 1323 WP_084445675.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-64)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11767.28 Da        Isoelectric Point: 7.2778

>T226483 WP_027353236.1 NZ_CP087952:2114466-2114762 [Desulfosarcina sp. BuS5]
MIKNFRDNWLRKFFVEDIQAKKIPADIRSRLFRKLQLLDDATNDADLRSPPSNHFEKLSGKLKDKCSIRVNDQWRLIFTW
DDEHGEANDIYIDDHSYK

Download         Length: 297 bp

>T226483 NZ_CP122499:909037-909444 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11496.46 Da        Isoelectric Point: 10.7602

>AT226483 WP_035264614.1 NZ_CP087952:2114771-2115082 [Desulfosarcina sp. BuS5]
MIITKRKPVSVGEMINEEFIAPLGITQGQLSSAMGVSRRTVNELCTGKRSITVDTALMLAKVFGNTANFWLNLQQRNDIW
AALHSPKRMEKIERVSPIREAIA

Download         Length: 312 bp

>AT226483 NZ_CP122499:908790-909056 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References