Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 1229605..1230175 Replicon chromosome
Accession NZ_CP087952
Organism Desulfosarcina sp. BuS5

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag BuS5_RS06090 Protein ID WP_027355152.1
Coordinates 1229888..1230175 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag BuS5_RS06085 Protein ID WP_027355151.1
Coordinates 1229605..1229883 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BuS5_RS06040 (BuS5_01240) 1224639..1225397 + 759 WP_027355102.1 WecB/TagA/CpsF family glycosyltransferase -
BuS5_RS06045 1225459..1226523 + 1065 Protein_1197 UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing) -
BuS5_RS06050 (BuS5_01243) 1226533..1226862 + 330 WP_051375273.1 WecB/TagA/CpsF family glycosyltransferase -
BuS5_RS06055 (BuS5_01244) 1226853..1227110 + 258 WP_027355179.1 UPF0175 family protein -
BuS5_RS06060 (BuS5_01245) 1227107..1227598 + 492 WP_027355180.1 DUF3368 domain-containing protein -
BuS5_RS06065 (BuS5_01246) 1227997..1228257 + 261 WP_274428105.1 hypothetical protein -
BuS5_RS06070 (BuS5_01247) 1228462..1228641 + 180 WP_274428106.1 hypothetical protein -
BuS5_RS06075 (BuS5_01248) 1228645..1228941 + 297 WP_051375310.1 hypothetical protein -
BuS5_RS06080 (BuS5_01249) 1228916..1229413 + 498 WP_051375308.1 WecB/TagA/CpsF family glycosyltransferase -
BuS5_RS06085 (BuS5_01250) 1229605..1229883 - 279 WP_027355151.1 HigA family addiction module antitoxin Antitoxin
BuS5_RS06090 (BuS5_01251) 1229888..1230175 - 288 WP_027355152.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BuS5_RS06095 (BuS5_01252) 1230348..1230503 + 156 WP_157487508.1 hypothetical protein -
BuS5_RS06100 (BuS5_01253) 1230568..1230828 - 261 WP_027355153.1 hypothetical protein -
BuS5_RS06105 1231109..1231267 - 159 WP_274428107.1 hypothetical protein -
BuS5_RS06110 1231658..1232722 + 1065 Protein_1210 UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing) -
BuS5_RS06115 (BuS5_01256) 1232732..1233061 + 330 WP_051375273.1 WecB/TagA/CpsF family glycosyltransferase -
BuS5_RS06120 (BuS5_01257) 1233052..1233309 + 258 WP_027355179.1 UPF0175 family protein -
BuS5_RS06125 (BuS5_01258) 1233306..1233797 + 492 WP_027355180.1 DUF3368 domain-containing protein -
BuS5_RS06130 (BuS5_01259) 1234196..1234456 + 261 WP_274428105.1 hypothetical protein -
BuS5_RS06135 (BuS5_01260) 1234661..1234840 + 180 WP_274428106.1 hypothetical protein -
BuS5_RS06140 (BuS5_01261) 1234844..1235140 + 297 WP_051375310.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(11-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(7-64)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10734.02 Da        Isoelectric Point: 8.9659

>T226480 WP_027355152.1 NZ_CP087952:c1230175-1229888 [Desulfosarcina sp. BuS5]
MIRSWGNSRSRRFYEEGKTSRFRGLDPDAADDLLAALDAAESLKDLSPLKSVGLHKLSGNRAGQWAMRANGPWRICFRFK
DGDAYDVEITDYHKG

Download         Length: 288 bp

>T226480 NZ_CP087952:c1230175-1229888 [Desulfosarcina sp. BuS5]
ATGATTCGCTCATGGGGCAACAGTCGCTCTCGACGCTTTTACGAAGAAGGCAAGACATCCAGATTTCGTGGCCTGGATCC
GGATGCTGCTGACGATTTGCTCGCTGCTCTTGATGCTGCAGAATCTCTAAAGGATTTAAGCCCATTAAAAAGTGTAGGCC
TGCACAAATTATCCGGTAATAGAGCAGGTCAATGGGCGATGAGGGCAAACGGGCCATGGCGGATCTGTTTTCGTTTTAAG
GACGGCGATGCGTATGATGTTGAAATTACAGATTACCACAAGGGGTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10327.12 Da        Isoelectric Point: 11.7821

>AT226480 WP_027355151.1 NZ_CP087952:c1229883-1229605 [Desulfosarcina sp. BuS5]
MKPIHPGRILKREMTARELSANKLALSLRVPSGRITQILNGKRGISAETALRLSRYFGNSARFWMNLQIRYELAITAHKI
GPKVNAEVEQAA

Download         Length: 279 bp

>AT226480 NZ_CP087952:c1229883-1229605 [Desulfosarcina sp. BuS5]
ATGAAACCAATTCACCCGGGACGTATTCTTAAACGTGAAATGACGGCACGCGAACTTTCGGCCAACAAACTTGCTCTATC
ATTGCGTGTACCTTCAGGGCGTATTACTCAAATCCTTAATGGCAAGCGTGGCATTAGTGCGGAAACAGCGTTGCGGCTTT
CCCGTTATTTTGGTAACAGCGCCCGCTTTTGGATGAATCTTCAAATCAGATACGAGCTGGCTATAACTGCACATAAGATC
GGCCCGAAAGTTAATGCCGAAGTCGAACAGGCAGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References