Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 964070..965510 Replicon chromosome
Accession NZ_CP087952
Organism Desulfosarcina sp. BuS5

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag BuS5_RS04720 Protein ID WP_027354943.1
Coordinates 964070..964408 (+) Length 113 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag BuS5_RS04725 Protein ID WP_035266443.1
Coordinates 964401..965510 (+) Length 370 a.a.

Genomic Context

BuS5_RS04710BuS5_RS04715BuS5_RS04720BuS5_RS04725BuS5_RS04730BuS5_RS04735BuS5_RS04740BuS5_RS04745BuS5_RS04750BuS5_RS04755BuS5_RS04690BuS5_RS04695BuS5_RS04700BuS5_RS04705
Location: 962391..963545 (1155 bp)
Type: Others
Protein ID: WP_036019371.1
Location: 963589..963711 (123 bp)
Type: Others
Protein ID: WP_274428048.1
Location: 964070..964408 (339 bp)
Type: Toxin
Protein ID: WP_027354943.1
Location: 964401..965510 (1110 bp)
Type: Antitoxin
Protein ID: WP_035266443.1
Location: 965930..966994 (1065 bp)
Type: Others
Protein ID: WP_027354941.1
Location: 966991..967278 (288 bp)
Type: Others
Protein ID: WP_035266442.1
Location: 967704..967943 (240 bp)
Type: Others
Protein ID: WP_027354939.1
Location: 967943..968281 (339 bp)
Type: Others
Protein ID: WP_027354938.1
Location: 969345..969650 (306 bp)
Type: Others
Protein ID: WP_027354937.1
Location: 969643..970068 (426 bp)
Type: Others
Protein ID: WP_051375151.1
Location: 959199..960164 (966 bp)
Type: Others
Protein ID: WP_157487501.1
Location: 960254..960958 (705 bp)
Type: Others
Protein ID: WP_274428046.1
Location: 960951..961199 (249 bp)
Type: Others
Protein ID: WP_027355009.1
Location: 961360..962277 (918 bp)
Type: Others
Protein ID: WP_274428047.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BuS5_RS04690 (BuS5_00968)959199..960164-966WP_157487501.1DUF2971 domain-containing protein-
BuS5_RS04695 (BuS5_00969)960254..960958-705WP_274428046.1hypothetical protein-
BuS5_RS04700 (BuS5_00970)960951..961199-249WP_027355009.1hypothetical protein-
BuS5_RS04705 (BuS5_00971)961360..962277-918WP_274428047.1hypothetical protein-
BuS5_RS04710 (BuS5_00972)962391..963545+1155WP_036019371.1IS4 family transposase-
BuS5_RS04715963589..963711+123WP_274428048.1hypothetical protein-
BuS5_RS04720 (BuS5_00973)964070..964408+339WP_027354943.1type II toxin-antitoxin system RelE/ParE family toxinToxin
BuS5_RS04725 (BuS5_00974)964401..965510+1110WP_035266443.1HigA family addiction module antitoxinAntitoxin
BuS5_RS04730 (BuS5_00975)965930..966994+1065WP_027354941.1hypothetical protein-
BuS5_RS04735 (BuS5_00976)966991..967278+288WP_035266442.1hypothetical protein-
BuS5_RS04740 (BuS5_00978)967704..967943+240WP_027354939.1MazF family transcriptional regulator-
BuS5_RS04745 (BuS5_00979)967943..968281+339WP_027354938.1endoribonuclease MazF-
BuS5_RS04750 (BuS5_00980)969345..969650+306WP_027354937.1nucleotidyltransferase domain-containing protein-
BuS5_RS04755 (BuS5_00981)969643..970068+426WP_051375151.1DUF86 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-80)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-73)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 13137.34 Da        Isoelectric Point: 10.5225

>T226477 WP_027354943.1 NZ_CP087952:964070-964408 [Desulfosarcina sp. BuS5]
MHIIFKTKRLEKELNFSKKLIKKYGSKTTRFIMRRMKVLAAANSLADVPHQPPERCHQLSGGRDEQFAVVIRDQWRLIFV
PNHETIPRKRDGGIELSQITAIEIIWIGDYHE

Download         Length: 339 bp

>T226477 NZ_CP122498:36492-36773 [Escherichia coli]
ATGACCTATGAACTGGCTTTTGACCGTAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAACTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATACCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCCGTTGGAAGA
AGGGAAAGCAGCGAAGTCTATCAGATCGCAGATTTGCGCTAA

Antitoxin


Download         Length: 370 a.a.        Molecular weight: 41890.34 Da        Isoelectric Point: 10.0916

>AT226477 WP_035266443.1 NZ_CP087952:964401-965510 [Desulfosarcina sp. BuS5]
MNNIETNAYQPDYTIHPGEILEETLEARGIKKTALAERCGITLKTVSQIINGKASISPSIAIRLERAIGVSASLWSNLNT
DYELFVAREKDHASLYKQKQWVKKFPLQQLSNLGILPRKKNLTENLSNLLSFFGVSTISAWNNFYLAPNVAYRRSVAYKS
QPESIATWLRIGELMSESVECAPFNKKKFKVALSEIRKVTNEPVEIFQKIMIESCRKSGVSLVFVPELSKTHVSGATKWL
NTNKAMIILSLRHKMDDHFWFNFFHEAGHILLHGKTEVFIEANNHIEKSEKEVEADVFASNILISKSNYKKLTSLTKFSR
QSISAFAKELDLSPGIIVGRLQHDGLIPYSWLNKLKRKFAFSAQQSHTL

Download         Length: 1110 bp

>AT226477 NZ_CP122498:36251-36502 [Escherichia coli]
ATGAGCTATCAAATTCTGACAACCACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References