Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 911757..912325 | Replicon | chromosome |
| Accession | NZ_CP087952 | ||
| Organism | Desulfosarcina sp. BuS5 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | BuS5_RS04415 | Protein ID | WP_027355190.1 |
| Coordinates | 911757..912035 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | BuS5_RS04420 | Protein ID | WP_027355191.1 |
| Coordinates | 912035..912325 (+) | Length | 97 a.a. |
Genomic Context
Location: 906860..907291 (432 bp)
Type: Others
Protein ID: WP_274428032.1
Type: Others
Protein ID: WP_274428032.1
Location: 907314..908432 (1119 bp)
Type: Others
Protein ID: Protein_869
Type: Others
Protein ID: Protein_869
Location: 909135..910290 (1156 bp)
Type: Others
Protein ID: Protein_870
Type: Others
Protein ID: Protein_870
Location: 910600..910866 (267 bp)
Type: Others
Protein ID: WP_274428033.1
Type: Others
Protein ID: WP_274428033.1
Location: 910905..911213 (309 bp)
Type: Others
Protein ID: WP_274427764.1
Type: Others
Protein ID: WP_274427764.1
Location: 911757..912035 (279 bp)
Type: Toxin
Protein ID: WP_027355190.1
Type: Toxin
Protein ID: WP_027355190.1
Location: 912035..912325 (291 bp)
Type: Antitoxin
Protein ID: WP_027355191.1
Type: Antitoxin
Protein ID: WP_027355191.1
Location: 913868..915020 (1153 bp)
Type: Others
Protein ID: Protein_877
Type: Others
Protein ID: Protein_877
Location: 915047..916465 (1419 bp)
Type: Others
Protein ID: WP_255342841.1
Type: Others
Protein ID: WP_255342841.1
Location: 912468..912701 (234 bp)
Type: Others
Protein ID: WP_274428034.1
Type: Others
Protein ID: WP_274428034.1
Location: 912923..913534 (612 bp)
Type: Others
Protein ID: WP_274428035.1
Type: Others
Protein ID: WP_274428035.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BuS5_RS04390 (BuS5_00900) | 906860..907291 | + | 432 | WP_274428032.1 | hypothetical protein | - |
| BuS5_RS04395 | 907314..908432 | + | 1119 | Protein_869 | IS3 family transposase | - |
| BuS5_RS04400 (BuS5_00904) | 909135..910290 | + | 1156 | Protein_870 | IS4 family transposase | - |
| BuS5_RS04405 (BuS5_00906) | 910600..910866 | + | 267 | WP_274428033.1 | reverse transcriptase domain-containing protein | - |
| BuS5_RS04410 (BuS5_00907) | 910905..911213 | + | 309 | WP_274427764.1 | group II intron maturase-specific domain-containing protein | - |
| BuS5_RS04415 (BuS5_00908) | 911757..912035 | + | 279 | WP_027355190.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| BuS5_RS04420 (BuS5_00909) | 912035..912325 | + | 291 | WP_027355191.1 | HigA family addiction module antitoxin | Antitoxin |
| BuS5_RS04425 (BuS5_00910) | 912468..912701 | - | 234 | WP_274428034.1 | hypothetical protein | - |
| BuS5_RS04430 (BuS5_00911) | 912923..913534 | - | 612 | WP_274428035.1 | hypothetical protein | - |
| BuS5_RS04435 (BuS5_00912) | 913868..915020 | + | 1153 | Protein_877 | IS4 family transposase | - |
| BuS5_RS04440 (BuS5_00915) | 915047..916465 | + | 1419 | WP_255342841.1 | N-6 DNA methylase | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 908217..908432 | 215 | |
| - | flank | IS/Tn | - | - | 914596..914784 | 188 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10851.61 Da Isoelectric Point: 10.4176
>T226476 WP_027355190.1 NZ_CP087952:911757-912035 [Desulfosarcina sp. BuS5]
MIKTFKHKGLRKFFENGNLAGIKPGHRQKLRLRLIALDTATCIEDMNIPGWRLHSLKGDHKGLWAIDVNRNWRIVFKFKD
GNAYIVDYEDYH
MIKTFKHKGLRKFFENGNLAGIKPGHRQKLRLRLIALDTATCIEDMNIPGWRLHSLKGDHKGLWAIDVNRNWRIVFKFKD
GNAYIVDYEDYH
Download Length: 279 bp
>T226476 NZ_CP122497:c37473-37096 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAGCTTACTGCAATTCATGATGCGAATATAAGCCGCTACGGCGGCCTGCCAGGCATGTC
AGATTCGGGAAGAGCTGAGGCTATTATCGGGAGAGTCCAGGCCAGAGTTGCATATGAAGAGATTACCGACCTTTTCGAAG
TCTCCGCAACTTACCTGGTGGCTACTGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
TTGTTATTTCTGCGCCGTAACGGTGTGCAGGTATATGATTCACCAGAACTGGCAGAGCTTACTGTGGGGGCTGCGACCGG
AGAGGTATCCGTATCTACTGTCGTTGCCACGTTACGTAGATTGTATGGTACGGCGTAG
ATGAGGCATATATCACCGGAAGAGCTTACTGCAATTCATGATGCGAATATAAGCCGCTACGGCGGCCTGCCAGGCATGTC
AGATTCGGGAAGAGCTGAGGCTATTATCGGGAGAGTCCAGGCCAGAGTTGCATATGAAGAGATTACCGACCTTTTCGAAG
TCTCCGCAACTTACCTGGTGGCTACTGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
TTGTTATTTCTGCGCCGTAACGGTGTGCAGGTATATGATTCACCAGAACTGGCAGAGCTTACTGTGGGGGCTGCGACCGG
AGAGGTATCCGTATCTACTGTCGTTGCCACGTTACGTAGATTGTATGGTACGGCGTAG
Antitoxin
Download Length: 97 a.a. Molecular weight: 10610.41 Da Isoelectric Point: 8.9642
>AT226476 WP_027355191.1 NZ_CP087952:912035-912325 [Desulfosarcina sp. BuS5]
MAMYNPPHPGEFIKDVYLEPLGVTPRGVALRLKVAPSTFSRLIKGQSSISPGMALRLSKCLGRSPESWLLMQDSYDLWKA
KQNVDLSDIEPLAIPA
MAMYNPPHPGEFIKDVYLEPLGVTPRGVALRLKVAPSTFSRLIKGQSSISPGMALRLSKCLGRSPESWLLMQDSYDLWKA
KQNVDLSDIEPLAIPA
Download Length: 291 bp
>AT226476 NZ_CP122497:c37694-37473 [Escherichia coli]
ATGCAATCTATTAACTTCCGTACCGCACGCAGCAATCTTACCGAAGTGCTCAACAATGTTGAAGCCGGAGAAGAGGTTGA
AATCACCCGTAGAGGCCGTGAGCCAGCTGTAATTGTCAGCAAGGCCACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTCGCATCCCTGTTTGACACTCTGGACACCACCAATAAGAAACTGGTTAACCGATAA
ATGCAATCTATTAACTTCCGTACCGCACGCAGCAATCTTACCGAAGTGCTCAACAATGTTGAAGCCGGAGAAGAGGTTGA
AATCACCCGTAGAGGCCGTGAGCCAGCTGTAATTGTCAGCAAGGCCACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTCGCATCCCTGTTTGACACTCTGGACACCACCAATAAGAAACTGGTTAACCGATAA