Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 808640..809313 Replicon chromosome
Accession NZ_CP087952
Organism Desulfosarcina sp. BuS5

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag BuS5_RS03875 Protein ID WP_232223113.1
Coordinates 808640..808999 (+) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag BuS5_RS03880 Protein ID WP_035266278.1
Coordinates 808996..809313 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BuS5_RS03835 (BuS5_00783) 803813..804745 - 933 WP_027354819.1 tyrosine-type recombinase/integrase -
BuS5_RS03840 (BuS5_00784) 804742..805662 - 921 WP_027354818.1 tyrosine-type recombinase/integrase -
BuS5_RS03845 (BuS5_00785) 805798..806184 + 387 WP_027354817.1 hypothetical protein -
BuS5_RS03850 (BuS5_00786) 806317..806529 + 213 WP_027354816.1 DUF2281 domain-containing protein -
BuS5_RS03855 (BuS5_00787) 806526..806873 + 348 WP_027354815.1 type II toxin-antitoxin system PemK/MazF family toxin -
BuS5_RS03860 (BuS5_00788) 807044..807430 + 387 WP_027354814.1 HEPN domain-containing protein -
BuS5_RS03865 (BuS5_00789) 807409..807726 + 318 WP_051375111.1 nucleotidyltransferase domain-containing protein -
BuS5_RS03870 (BuS5_00790) 808234..808515 + 282 WP_198012311.1 hypothetical protein -
BuS5_RS03875 (BuS5_00791) 808640..808999 + 360 WP_232223113.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BuS5_RS03880 (BuS5_00792) 808996..809313 + 318 WP_035266278.1 helix-turn-helix transcriptional regulator Antitoxin
BuS5_RS03885 (BuS5_00793) 810119..810286 + 168 WP_157487459.1 hypothetical protein -
BuS5_RS03890 (BuS5_00794) 810270..811226 + 957 WP_051375108.1 hypothetical protein -
BuS5_RS03895 (BuS5_00795) 811436..811930 + 495 WP_157487458.1 hypothetical protein -
BuS5_RS03900 (BuS5_00796) 812266..813123 + 858 WP_027354808.1 EamA family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 797983..825132 27149


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(26-114)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-90)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13843.51 Da        Isoelectric Point: 10.4689

>T226475 WP_232223113.1 NZ_CP087952:808640-808999 [Desulfosarcina sp. BuS5]
MQDINVSVNIVFMTWKILYYSEALQEEISTLPAGIQARYIHLTERMRHYGANLGMPHTKALKEGLFELRMKSKEGIGRIF
YCTLLGKKIVMLHTFIKKSQKTPQKELKIAISRMNEVKK

Download         Length: 360 bp

>T226475 NZ_CP122497:c30837-30316 [Escherichia coli]
GTGAGCAATACGACGATCGAGATTTTCTCTGGAGAGAAAGATTATGATCTAAACGGTTTTGATTGCGGCGAAGAGTCACT
AAACGCATTTTTGACCAACCACTTAAAAAGACAGCATGAAGGAAAAATTCTTCGCGCTTATGTGCTTTGCACTAAAGAAG
AAATACCAAAGGTATTAGGTTATTACACTTTGTCAGGCAGCTGCTTTGAGAAAGAAACCTTACCTTCAAAGAGTCAGCAA
AAGAAAGTGCCTTATCGGAATGTCCCAAGTATCACTTTAGGCAGACTGGCTTTGGACAAATCTCTTCAAGGTCAGGGGCT
TGGCTCAATGCTTGTAACTCACGCAATGCGTGTTGTGTACAATGCATCTCTTGCGGTAGGCATTCATGGGCTTTTCGTTG
AGGCGTTGAACGATAAAGCCAGGGCGTTTTATAAAAGTTTGGGCTTTATCCAGCTGGTTGGTAACAACGATCGTTCTTTG
TTCTATCCAACAAAATCTATCGAAAAATTGTTCGAAGAATAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11654.46 Da        Isoelectric Point: 9.8516

>AT226475 WP_035266278.1 NZ_CP087952:808996-809313 [Desulfosarcina sp. BuS5]
MMTHEEFTKKLLQNPEVQKEYDALDDEFSLFDELLKARIKAGLTQAEVADRMGTKTPAIARLEAGGGNKKHSPSVSTLRK
YAKAVGCHLEIKLVRKGSNMKISHG

Download         Length: 318 bp

>AT226475 NZ_CP122497:c31114-30845 [Escherichia coli]
ATGTCCGCACTGAAAAAGCAGCGCATCGATTTGAGATTAACCGATGACGATAAAAGCATCATCGAGGAAGCTGCCGCAAT
GTCTAACCAGAGCATTACCCAGTTCATGGTTAGCAGTGCATCCGAACGTGCCGTGAAGGTGATAGAGCAACACCGTAGAC
TGGTTCTAAGTGAAGAGTCCTGGAATCTGGTTATGGATGCTATAAGCAATCCTCCGGCACCGAACGACAAGCTGAAACGA
GCTGCCAATCGTCTGAAAAGCATGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References