Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2101715..2102415 Replicon chromosome
Accession NZ_CP087880
Organism Pseudocitrobacter corydidari isolate G163CM

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag G163CM_RS09765 Protein ID WP_231827863.1
Coordinates 2101715..2102020 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag G163CM_RS09770 Protein ID WP_231827864.1
Coordinates 2102074..2102415 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G163CM_RS09740 (2097624) 2097624..2098346 - 723 WP_231828354.1 oxygen-insensitive NADPH nitroreductase -
G163CM_RS09745 (2098330) 2098330..2098620 - 291 WP_231827862.1 DUF1418 family protein -
G163CM_RS09750 (2098803) 2098803..2099066 + 264 WP_015965155.1 GrxA family glutaredoxin -
G163CM_RS09755 (2099063) 2099063..2099470 - 408 WP_015965156.1 inner membrane protein YbjM -
G163CM_RS09760 (2099745) 2099745..2101430 + 1686 WP_108474643.1 aspartate:alanine antiporter -
G163CM_RS09765 (2101715) 2101715..2102020 + 306 WP_231827863.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G163CM_RS09770 (2102074) 2102074..2102415 + 342 WP_231827864.1 HigA family addiction module antitoxin Antitoxin
G163CM_RS09775 (2102418) 2102418..2102960 - 543 WP_231827865.1 TetR family transcriptional regulator -
G163CM_RS09780 (2103036) 2103036..2104244 + 1209 WP_231827866.1 MFS transporter -
G163CM_RS09785 (2104241) 2104241..2105053 + 813 WP_231827867.1 Cof-type HAD-IIB family hydrolase -
G163CM_RS09790 (2105088) 2105088..2106323 - 1236 WP_231827868.1 MFS transporter -
G163CM_RS09795 (2106591) 2106591..2107199 + 609 WP_015965162.1 undecaprenyl-diphosphate phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(10-99)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-70)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11862.60 Da        Isoelectric Point: 9.9506

>T226445 WP_231827863.1 NZ_CP087880:2101715-2102020 [Pseudocitrobacter corydidari]
MPQKLFNIGSFRDRWLADFFNYAAPHKLIPGEIHSGLARKLDIINAATCWQDLKSPPGNRYERLQGKLKGYSSIRVNKQY
RVIFKWTDGKAYDLYLDPHEY

Download         Length: 306 bp

>T226445 NZ_CP122492:2726167-2726274 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12955.89 Da        Isoelectric Point: 7.0139

>AT226445 WP_231827864.1 NZ_CP087880:2102074-2102415 [Pseudocitrobacter corydidari]
MNQATRKPTTPGDILLYEFLEPLNLKINDLAEMLQVHRNTVSALVNNNRKLTTDMAFRLAIVFNTSAEFWLNLQSAIDIW
KIENNPRTQLELSRIITAEDFIAARKQQAKDVA

Download         Length: 342 bp

>AT226445 NZ_CP122492:c2726120-2726054 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References