Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1712134..1712646 Replicon chromosome
Accession NC_010380
Organism Streptococcus pneumoniae Hungary19A-6

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DNR3
Locus tag SPH_RS09015 Protein ID WP_000924721.1
Coordinates 1712134..1712388 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID K0ZY22
Locus tag SPH_RS09020 Protein ID WP_000388572.1
Coordinates 1712392..1712646 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SPH_RS09000 1709235..1709549 - 315 WP_000979235.1 DNA-directed RNA polymerase subunit omega -
SPH_RS09005 1709574..1710200 - 627 WP_000775037.1 guanylate kinase -
SPH_RS09010 1710330..1711943 - 1614 WP_000404940.1 ribonuclease Y -
SPH_RS09015 1712134..1712388 - 255 WP_000924721.1 Txe/YoeB family addiction module toxin Toxin
SPH_RS09020 1712392..1712646 - 255 WP_000388572.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SPH_RS09025 1712884..1713981 - 1098 WP_000156335.1 nucleotidyltransferase -
SPH_RS09030 1713991..1714731 - 741 WP_000257071.1 class I SAM-dependent methyltransferase -
SPH_RS09035 1715051..1715404 - 354 WP_001003001.1 ribosome silencing factor -
SPH_RS09040 1715417..1715917 - 501 WP_000844707.1 cysteine hydrolase -
SPH_RS09045 1715918..1716511 - 594 WP_000121666.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
SPH_RS09050 1716511..1717140 - 630 WP_000151313.1 nicotinate-nucleotide adenylyltransferase -
SPH_RS09055 1717192..1717503 - 312 WP_000060169.1 ribosome assembly RNA-binding protein YhbY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10115.55 Da        Isoelectric Point: 7.9716

>T22644 WP_000924721.1 NC_010380:c1712388-1712134 [Streptococcus pneumoniae Hungary19A-6]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSF
KDHY

Download         Length: 255 bp

>T22644 NC_010380:c1712388-1712134 [Streptococcus pneumoniae Hungary19A-6]
ATGCTACTCAAGTTTACAGAAGATGCCTGGGCAGATTATTGCTACTGGCAAAACCAAGATAAAAAAACACTAAAAAGAAT
CAATAAATTAATCAAGGATATTCAACGCGATCCATTTACAGGAATAGGAAAACCAGAGCCACTCAAATATGATTACCAAG
GAGCCTGGTCACGGCGTATTGATGCAGAAAATCGCTTGATTTATATGATGGATGGAGATAGCGTGGCTTTCTTGTCCTTT
AAAGATCATTACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9706.00 Da        Isoelectric Point: 4.8430

>AT22644 WP_000388572.1 NC_010380:c1712646-1712392 [Streptococcus pneumoniae Hungary19A-6]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE

Download         Length: 255 bp

>AT22644 NC_010380:c1712646-1712392 [Streptococcus pneumoniae Hungary19A-6]
ATGGAAGCAGTCCTTTACTCAACATTCCGAAATCATTTAAAGGACTACATGAAGAAGGTAAATGATGAATTTGAGCCTTT
GACGGTGGTCAATAAAAATCCAGATGAGGACATTGTAGTTCTTTCAAAGAGCGAATGGGACAGTATTCAGGAAACCCTGA
GAATCGCCCAAAATAAGGAGTTATCAGACAAGGTTTTGCGAGGAATGGCTCAAGTCCGTGCTGGAAGCACTCAGGTCCAT
GTGATTGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7LEN4

Antitoxin

Source ID Structure
AlphaFold DB K0ZY22

References