Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1808802..1809400 Replicon chromosome
Accession NZ_CP087859
Organism Moraxella bovis strain SAM57983

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LP093_RS09030 Protein ID WP_078275306.1
Coordinates 1808802..1809080 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag LP093_RS09035 Protein ID WP_078275307.1
Coordinates 1809095..1809400 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP093_RS09025 (LP093_08935) 1808132..1808716 - 585 WP_264676215.1 tail assembly protein -
LP093_RS09030 (LP093_08940) 1808802..1809080 + 279 WP_078275306.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LP093_RS09035 (LP093_08945) 1809095..1809400 + 306 WP_078275307.1 HigA family addiction module antitoxin Antitoxin
LP093_RS09040 (LP093_08950) 1809372..1810148 - 777 WP_078275308.1 C40 family peptidase -
LP093_RS09045 (LP093_08955) 1810216..1810404 - 189 WP_078275309.1 hypothetical protein -
LP093_RS09050 (LP093_08960) 1810401..1810997 - 597 WP_264676214.1 antA/AntB antirepressor family protein -
LP093_RS09055 (LP093_08965) 1811170..1811400 + 231 WP_078275311.1 Arc family DNA-binding protein -
LP093_RS09060 (LP093_08970) 1811442..1812125 - 684 WP_078275312.1 phage minor tail protein L -
LP093_RS09065 (LP093_08975) 1812122..1812511 - 390 WP_078275313.1 hypothetical protein -
LP093_RS09070 (LP093_08980) 1812547..1812879 - 333 WP_078275314.1 phage tail protein -
LP093_RS09075 (LP093_08985) 1812876..1813037 - 162 WP_158079719.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1793388..1847378 53990


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-95)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10491.92 Da        Isoelectric Point: 5.0474

>T226405 WP_078275306.1 NZ_CP087859:1808802-1809080 [Moraxella bovis]
MIQSFKCKDAQSLFETGSSRVFANFLSVATRKLTMLDNAVALADLRIPPANRLEKLTGDREGQYSIRINDQFRICFVWGD
DGVYDVEIVDYH

Download         Length: 279 bp

>T226405 NZ_CP122460:490252-490602 [Bacillus velezensis]
TTGATTGTAAAGCGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGCGTACGCCCGGT
TTTAGTGATCCAAAATGATATCGGAAATCGCTTTAGCCCGACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATTGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGATTAACGGATAAAATAACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
GCAAATCAGTTTGGCACTCATTGATTTTTAG

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11173.81 Da        Isoelectric Point: 7.3174

>AT226405 WP_078275307.1 NZ_CP087859:1809095-1809400 [Moraxella bovis]
MFKNGMRPVHAGEVLREEYLIPMGMSATALANALGVTPARINDIVRQRRGVTADTALRLARYFGGTAQFWLNLQTTYELR
LAETTLGDSLDFISPHEVAHA

Download         Length: 306 bp

>AT226405 NZ_CP122460:489965-490246 [Bacillus velezensis]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCTGAAAACTTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGGACAACTCGCCATAACC
GTGATTTGATGAGACGCGGGTATATGGAAATGGCGAAAATCAACTTGAATATCTCTTCTGAGGCTCACTATGCTGAGTGC
GAAGCAGAAACGACCGTTGAGCGCTTAGTCAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References