Detailed information of TA system TA226397

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 2630318..2630924
• Replicon: chromosome
• Accession: NZ_CP087856
• Organism: Moraxella bovis strain SAM57987

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: LP115_RS13480
• Protein ID: WP_228157738.1
• Coordinates: 2630318..2630653 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: LP115_RS13485
• Protein ID: WP_078274722.1
• Coordinates: 2630643..2630924 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP115_RS13435	2625379..2625513	+	135	WP_264676041.1	hypothetical protein	-
LP115_RS13440 (LP115_13320)	2625565..2625720	+	156	WP_158079680.1	hypothetical protein	-
LP115_RS13445 (LP115_13325)	2625715..2625990	-	276	WP_078274708.1	hypothetical protein	-
LP115_RS13450 (LP115_13330)	2626277..2626522	-	246	WP_078274709.1	hypothetical protein	-
LP115_RS13455 (LP115_13335)	2626645..2626974	-	330	WP_264676042.1	hypothetical protein	-
LP115_RS13460 (LP115_13340)	2627093..2627350	+	258	WP_112741693.1	hypothetical protein	-
LP115_RS13465 (LP115_13345)	2627843..2628718	+	876	WP_162860331.1	virulence factor TspB C-terminal domain-related protein	-
LP115_RS13470 (LP115_13350)	2628715..2629008	+	294	WP_078274720.1	DUF2523 family protein	-
LP115_RS13475 (LP115_13355)	2629094..2630254	+	1161	WP_078274721.1	zonular occludens toxin domain-containing protein	-
LP115_RS13480 (LP115_13360)	2630318..2630653	+	336	WP_228157738.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LP115_RS13485 (LP115_13365)	2630643..2630924	+	282	WP_078274722.1	NadS family protein	Antitoxin
LP115_RS13490 (LP115_13370)	2630974..2631798	+	825	WP_078274723.1	site-specific integrase	-
LP115_RS13495 (LP115_13375)	2631914..2632126	+	213	WP_078274724.1	hypothetical protein	-
LP115_RS13500 (LP115_13380)	2632166..2632888	-	723	WP_029103568.1	nitroreductase family protein	-
LP115_RS13505 (LP115_13385)	2633033..2634358	-	1326	WP_112741690.1	hemolysin family protein	-
LP115_RS13510 (LP115_13390)	2634468..2635226	-	759	WP_078274726.1	YciK family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (43-106)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-84)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 12636.69 Da
• Isoelectric Point: 10.0972

>T226397 WP_228157738.1 NZ_CP087856:2630318-2630653 [Moraxella bovis]
MLHFAETSLFTKQIIDLMDDDEYRLLQTNLMKNPHQGDIVRGTGGVRKTRWSIDGKGKSGGSRIIYFFVDGAGIFFMLLA
YPKSKQTTLSADEKKEMLKLTTAIKEIYRAK

Nucleotide

• Length: 336 bp

>T226397 NZ_CP122457:c2294114-2293830 [Salmonella enterica subsp. enterica]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGACTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGACTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAATGACACGACACAGAAGCTAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10425.98 Da
• Isoelectric Point: 10.0023

>AT226397 WP_078274722.1 NZ_CP087856:2630643-2630924 [Moraxella bovis]
VQNEFYDDLKASLTEALAIAKGEISPSRTFTYERPNIKDIRAKTGLSQTQFAQKLHISPKTLKNWEQGIRTPTGPAITLI
RLLDKNPDLISMA

Nucleotide

• Length: 282 bp

>AT226397 NZ_CP122457:c2294352-2294104 [Salmonella enterica subsp. enterica]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGATCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGCAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA