Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 926398..926996 Replicon chromosome
Accession NZ_CP087856
Organism Moraxella bovis strain SAM57987

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LP115_RS04950 Protein ID WP_078275306.1
Coordinates 926718..926996 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag LP115_RS04945 Protein ID WP_078275307.1
Coordinates 926398..926703 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP115_RS04910 (LP115_04885) 922919..923251 + 333 WP_078275314.1 phage tail protein -
LP115_RS04915 (LP115_04890) 923287..923676 + 390 WP_078275313.1 hypothetical protein -
LP115_RS04920 (LP115_04895) 923673..924356 + 684 WP_264676213.1 phage minor tail protein L -
LP115_RS04925 (LP115_04900) 924398..924628 - 231 WP_078275311.1 Arc family DNA-binding protein -
LP115_RS04930 (LP115_04905) 924801..925397 + 597 WP_264676214.1 antA/AntB antirepressor family protein -
LP115_RS04935 (LP115_04910) 925394..925582 + 189 WP_078275309.1 hypothetical protein -
LP115_RS04940 (LP115_04915) 925650..926426 + 777 WP_078275308.1 C40 family peptidase -
LP115_RS04945 (LP115_04920) 926398..926703 - 306 WP_078275307.1 HigA family addiction module antitoxin Antitoxin
LP115_RS04950 (LP115_04925) 926718..926996 - 279 WP_078275306.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LP115_RS04955 (LP115_04930) 927082..927666 + 585 WP_264676215.1 tail assembly protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 887556..942410 54854


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-95)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10491.92 Da        Isoelectric Point: 5.0474

>T226390 WP_078275306.1 NZ_CP087856:c926996-926718 [Moraxella bovis]
MIQSFKCKDAQSLFETGSSRVFANFLSVATRKLTMLDNAVALADLRIPPANRLEKLTGDREGQYSIRINDQFRICFVWGD
DGVYDVEIVDYH

Download         Length: 279 bp

>T226390 NZ_CP122454:c4947402-4947091 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGAACGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTCTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11173.81 Da        Isoelectric Point: 7.3174

>AT226390 WP_078275307.1 NZ_CP087856:c926703-926398 [Moraxella bovis]
MFKNGMRPVHAGEVLREEYLIPMGMSATALANALGVTPARINDIVRQRRGVTADTALRLARYFGGTAQFWLNLQTTYELR
LAETTLGDSLDFISPHEVAHA

Download         Length: 306 bp

>AT226390 NZ_CP122454:c4947090-4946800 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
ACGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References