Detailed information of TA system TA226386

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 2759902..2760508
• Replicon: chromosome
• Accession: NZ_CP087854
• Organism: Moraxella bovis strain SAM57990

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: LP113_RS14100
• Protein ID: WP_228157738.1
• Coordinates: 2759902..2760237 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: LP113_RS14105
• Protein ID: WP_078274722.1
• Coordinates: 2760227..2760508 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP113_RS14055	2754963..2755097	+	135	WP_264676041.1	hypothetical protein	-
LP113_RS14060 (LP113_13950)	2755149..2755304	+	156	WP_158079680.1	hypothetical protein	-
LP113_RS14065 (LP113_13955)	2755299..2755574	-	276	WP_078274708.1	hypothetical protein	-
LP113_RS14070 (LP113_13960)	2755861..2756106	-	246	WP_078274709.1	hypothetical protein	-
LP113_RS14075 (LP113_13965)	2756229..2756606	-	378	WP_264684286.1	hypothetical protein	-
LP113_RS14080 (LP113_13970)	2756605..2756934	+	330	WP_264684287.1	hypothetical protein	-
LP113_RS14085 (LP113_13975)	2757427..2758302	+	876	WP_162860331.1	virulence factor TspB C-terminal domain-related protein	-
LP113_RS14090 (LP113_13980)	2758299..2758592	+	294	WP_078274720.1	DUF2523 family protein	-
LP113_RS14095 (LP113_13985)	2758678..2759838	+	1161	WP_078274721.1	zonular occludens toxin domain-containing protein	-
LP113_RS14100 (LP113_13990)	2759902..2760237	+	336	WP_228157738.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LP113_RS14105 (LP113_13995)	2760227..2760508	+	282	WP_078274722.1	NadS family protein	Antitoxin
LP113_RS14110 (LP113_14000)	2760558..2761382	+	825	WP_264689883.1	site-specific integrase	-
LP113_RS14115 (LP113_14005)	2761498..2761710	+	213	WP_078274724.1	hypothetical protein	-
LP113_RS14120 (LP113_14010)	2761750..2762472	-	723	WP_029103568.1	nitroreductase family protein	-
LP113_RS14125 (LP113_14015)	2762617..2763942	-	1326	WP_112741690.1	hemolysin family protein	-
LP113_RS14130 (LP113_14020)	2764052..2764810	-	759	WP_078274726.1	YciK family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (43-106)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-84)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 12636.69 Da
• Isoelectric Point: 10.0972

>T226386 WP_228157738.1 NZ_CP087854:2759902-2760237 [Moraxella bovis]
MLHFAETSLFTKQIIDLMDDDEYRLLQTNLMKNPHQGDIVRGTGGVRKTRWSIDGKGKSGGSRIIYFFVDGAGIFFMLLA
YPKSKQTTLSADEKKEMLKLTTAIKEIYRAK

Nucleotide

• Length: 336 bp

>T226386 NZ_CP122454:c4182743-4182408 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATACGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTCTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10425.98 Da
• Isoelectric Point: 10.0023

>AT226386 WP_078274722.1 NZ_CP087854:2760227-2760508 [Moraxella bovis]
VQNEFYDDLKASLTEALAIAKGEISPSRTFTYERPNIKDIRAKTGLSQTQFAQKLHISPKTLKNWEQGIRTPTGPAITLI
RLLDKNPDLISMA

Nucleotide

• Length: 282 bp

>AT226386 NZ_CP122454:c4182991-4182743 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGATCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGGGAGCCGAAAGATAAGGAA
GTCTGGTAA