Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1869835..1870433 Replicon chromosome
Accession NZ_CP087854
Organism Moraxella bovis strain SAM57990

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LP113_RS09380 Protein ID WP_078275306.1
Coordinates 1869835..1870113 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LP113_RS09385 Protein ID WP_276001721.1
Coordinates 1870143..1870433 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP113_RS09375 (LP113_09300) 1869165..1869749 - 585 WP_264676215.1 tail assembly protein -
LP113_RS09380 (LP113_09305) 1869835..1870113 + 279 WP_078275306.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LP113_RS09385 (LP113_09310) 1870143..1870433 + 291 WP_276001721.1 HigA family addiction module antitoxin Antitoxin
LP113_RS09390 (LP113_09315) 1870405..1871181 - 777 WP_112742102.1 C40 family peptidase -
LP113_RS09395 (LP113_09320) 1871249..1871437 - 189 WP_078275309.1 hypothetical protein -
LP113_RS09400 (LP113_09325) 1871434..1871976 - 543 WP_078275310.1 antA/AntB antirepressor family protein -
LP113_RS09405 (LP113_09330) 1872149..1872379 + 231 WP_078275311.1 Arc family DNA-binding protein -
LP113_RS09410 (LP113_09335) 1872421..1873104 - 684 WP_078275312.1 phage minor tail protein L -
LP113_RS09415 (LP113_09340) 1873101..1873490 - 390 WP_078275313.1 hypothetical protein -
LP113_RS09420 (LP113_09345) 1873526..1873858 - 333 WP_078275314.1 phage tail protein -
LP113_RS09425 (LP113_09350) 1873855..1874016 - 162 WP_158079719.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1860832..1907287 46455


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-90)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10491.92 Da        Isoelectric Point: 5.0474

>T226381 WP_078275306.1 NZ_CP087854:1869835-1870113 [Moraxella bovis]
MIQSFKCKDAQSLFETGSSRVFANFLSVATRKLTMLDNAVALADLRIPPANRLEKLTGDREGQYSIRINDQFRICFVWGD
DGVYDVEIVDYH

Download         Length: 279 bp

>T226381 NZ_CP122454:c3131733-3131631 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10596.11 Da        Isoelectric Point: 6.7228

>AT226381 WP_276001721.1 NZ_CP087854:1870143-1870433 [Moraxella bovis]
MRPVHAGEVLREEYLIPMGMSATALANALGVTPARINDIVRQRRGVTADTALRLARYFGGTAQFWLNLQTTYELRLAETT
LGDSLDFISPHEVAHA

Download         Length: 291 bp

>AT226381 NZ_CP122454:3131593-3131861 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References