Detailed information of TA system TA226376

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 2636274..2636880
• Replicon: chromosome
• Accession: NZ_CP087851
• Organism: Moraxella bovis strain SAM57991

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: LP094_RS13515
• Protein ID: WP_228157738.1
• Coordinates: 2636274..2636609 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: LP094_RS13520
• Protein ID: WP_078274722.1
• Coordinates: 2636599..2636880 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP094_RS13470	2631335..2631469	+	135	WP_264676041.1	hypothetical protein	-
LP094_RS13475 (LP094_13355)	2631521..2631676	+	156	WP_158079680.1	hypothetical protein	-
LP094_RS13480 (LP094_13360)	2631671..2631946	-	276	WP_078274708.1	hypothetical protein	-
LP094_RS13485 (LP094_13365)	2632233..2632478	-	246	WP_078274709.1	hypothetical protein	-
LP094_RS13490 (LP094_13370)	2632601..2632930	-	330	WP_264676042.1	hypothetical protein	-
LP094_RS13495 (LP094_13375)	2633049..2633306	+	258	WP_112741693.1	hypothetical protein	-
LP094_RS13500 (LP094_13380)	2633799..2634674	+	876	WP_162860331.1	virulence factor TspB C-terminal domain-related protein	-
LP094_RS13505 (LP094_13385)	2634671..2634964	+	294	WP_078274720.1	DUF2523 family protein	-
LP094_RS13510 (LP094_13390)	2635050..2636210	+	1161	WP_078274721.1	zonular occludens toxin domain-containing protein	-
LP094_RS13515 (LP094_13395)	2636274..2636609	+	336	WP_228157738.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LP094_RS13520 (LP094_13400)	2636599..2636880	+	282	WP_078274722.1	NadS family protein	Antitoxin
LP094_RS13525 (LP094_13405)	2636930..2637754	+	825	WP_078274723.1	site-specific integrase	-
LP094_RS13530 (LP094_13410)	2637870..2638082	+	213	WP_078274724.1	hypothetical protein	-
LP094_RS13535 (LP094_13415)	2638122..2638844	-	723	WP_029103568.1	nitroreductase family protein	-
LP094_RS13540 (LP094_13420)	2638989..2640314	-	1326	WP_112741690.1	hemolysin family protein	-
LP094_RS13545 (LP094_13425)	2640424..2641182	-	759	WP_078274726.1	YciK family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (43-106)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-84)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 12636.69 Da
• Isoelectric Point: 10.0972

>T226376 WP_228157738.1 NZ_CP087851:2636274-2636609 [Moraxella bovis]
MLHFAETSLFTKQIIDLMDDDEYRLLQTNLMKNPHQGDIVRGTGGVRKTRWSIDGKGKSGGSRIIYFFVDGAGIFFMLLA
YPKSKQTTLSADEKKEMLKLTTAIKEIYRAK

Nucleotide

• Length: 336 bp

>T226376 NZ_CP122454:c1569004-1568786 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10425.98 Da
• Isoelectric Point: 10.0023

>AT226376 WP_078274722.1 NZ_CP087851:2636599-2636880 [Moraxella bovis]
VQNEFYDDLKASLTEALAIAKGEISPSRTFTYERPNIKDIRAKTGLSQTQFAQKLHISPKTLKNWEQGIRTPTGPAITLI
RLLDKNPDLISMA

Nucleotide

• Length: 282 bp

>AT226376 NZ_CP122454:c1569404-1569030 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG