Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 925743..926341 Replicon chromosome
Accession NZ_CP087851
Organism Moraxella bovis strain SAM57991

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LP094_RS04950 Protein ID WP_078275306.1
Coordinates 926063..926341 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag LP094_RS04945 Protein ID WP_078275307.1
Coordinates 925743..926048 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP094_RS04905 (LP094_04885) 922106..922267 + 162 WP_158079719.1 hypothetical protein -
LP094_RS04910 (LP094_04890) 922264..922596 + 333 WP_078275314.1 phage tail protein -
LP094_RS04915 (LP094_04895) 922632..923021 + 390 WP_078275313.1 hypothetical protein -
LP094_RS04920 (LP094_04900) 923018..923701 + 684 WP_264676213.1 phage minor tail protein L -
LP094_RS04925 (LP094_04905) 923743..923973 - 231 WP_078275311.1 Arc family DNA-binding protein -
LP094_RS04930 (LP094_04910) 924146..924742 + 597 WP_264676214.1 antA/AntB antirepressor family protein -
LP094_RS04935 (LP094_04915) 924739..924927 + 189 WP_078275309.1 hypothetical protein -
LP094_RS04940 (LP094_04920) 924995..925771 + 777 WP_078275308.1 C40 family peptidase -
LP094_RS04945 (LP094_04925) 925743..926048 - 306 WP_078275307.1 HigA family addiction module antitoxin Antitoxin
LP094_RS04950 (LP094_04930) 926063..926341 - 279 WP_078275306.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LP094_RS04955 (LP094_04935) 926427..927011 + 585 WP_264676215.1 tail assembly protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 887360..941755 54395


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-95)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10491.92 Da        Isoelectric Point: 5.0474

>T226369 WP_078275306.1 NZ_CP087851:c926341-926063 [Moraxella bovis]
MIQSFKCKDAQSLFETGSSRVFANFLSVATRKLTMLDNAVALADLRIPPANRLEKLTGDREGQYSIRINDQFRICFVWGD
DGVYDVEIVDYH

Download         Length: 279 bp

>T226369 NZ_CP122453:4190-4465 [Escherichia coli]
ATGGAACTGAAGTGGACCAGTAAGGCACTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTACTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTGCAGTCCCTGACACAGGCGCCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTATGAACTTACTGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11173.81 Da        Isoelectric Point: 7.3174

>AT226369 WP_078275307.1 NZ_CP087851:c926048-925743 [Moraxella bovis]
MFKNGMRPVHAGEVLREEYLIPMGMSATALANALGVTPARINDIVRQRRGVTADTALRLARYFGGTAQFWLNLQTTYELR
LAETTLGDSLDFISPHEVAHA

Download         Length: 306 bp

>AT226369 NZ_CP122453:3906-4190 [Escherichia coli]
ATGCAAATGAAAAACAATACCGCACAAACAACAAAAGTCATTACCGCGCATGTGCCATTACCTATGGCTGATAAAATCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGCTGGATTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
GCAGACAGCCTCAATACTGACAATCCGTTACCGGTGCCTCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References