Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 912834..913432 Replicon chromosome
Accession NZ_CP087848
Organism Moraxella bovis strain SAM57994

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LP114_RS04740 Protein ID WP_078275306.1
Coordinates 913154..913432 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag LP114_RS04735 Protein ID WP_078275307.1
Coordinates 912834..913139 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP114_RS04700 (LP114_04675) 909409..909741 + 333 WP_078275314.1 phage tail protein -
LP114_RS04705 (LP114_04680) 909777..910166 + 390 WP_078275313.1 hypothetical protein -
LP114_RS04710 (LP114_04685) 910163..910846 + 684 WP_078275312.1 phage minor tail protein L -
LP114_RS04715 (LP114_04690) 910888..911118 - 231 WP_078275311.1 Arc family DNA-binding protein -
LP114_RS04720 (LP114_04695) 911291..911833 + 543 WP_078275310.1 antA/AntB antirepressor family protein -
LP114_RS04725 (LP114_04700) 911830..912018 + 189 WP_078275309.1 hypothetical protein -
LP114_RS04730 (LP114_04705) 912086..912862 + 777 WP_112742102.1 C40 family peptidase -
LP114_RS04735 (LP114_04710) 912834..913139 - 306 WP_078275307.1 HigA family addiction module antitoxin Antitoxin
LP114_RS04740 (LP114_04715) 913154..913432 - 279 WP_078275306.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LP114_RS04745 (LP114_04720) 913518..914102 + 585 WP_264676215.1 tail assembly protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 886179..922435 36256


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-95)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10491.92 Da        Isoelectric Point: 5.0474

>T226361 WP_078275306.1 NZ_CP087848:c913432-913154 [Moraxella bovis]
MIQSFKCKDAQSLFETGSSRVFANFLSVATRKLTMLDNAVALADLRIPPANRLEKLTGDREGQYSIRINDQFRICFVWGD
DGVYDVEIVDYH

Download         Length: 279 bp

>T226361 NZ_CP122451:c3025818-3025438 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTTGTTGAAAAATACGCGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGTCCCGTCGCAGTTAATCAACAGCATCGATATTCTCCGGGCCCGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATGACATTACCCTGGGCAGGCATCCGGAGGAGGCGAAACAATGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11173.81 Da        Isoelectric Point: 7.3174

>AT226361 WP_078275307.1 NZ_CP087848:c913139-912834 [Moraxella bovis]
MFKNGMRPVHAGEVLREEYLIPMGMSATALANALGVTPARINDIVRQRRGVTADTALRLARYFGGTAQFWLNLQTTYELR
LAETTLGDSLDFISPHEVAHA

Download         Length: 306 bp

>AT226361 NZ_CP122451:c3026239-3025865 [Escherichia coli]
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCAGT
TCAGCGACGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References