Detailed information of TA system TA226356

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 100043..100649
• Replicon: chromosome
• Accession: NZ_CP087848
• Organism: Moraxella bovis strain SAM57994

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: LP114_RS00495
• Protein ID: WP_228157738.1
• Coordinates: 100314..100649 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: LP114_RS00490
• Protein ID: WP_078274722.1
• Coordinates: 100043..100324 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP114_RS00465 (LP114_00465)	95741..96499	+	759	WP_078274726.1	YciK family oxidoreductase	-
LP114_RS00470 (LP114_00470)	96609..97934	+	1326	WP_112741690.1	hemolysin family protein	-
LP114_RS00475 (LP114_00475)	98079..98801	+	723	WP_029103568.1	nitroreductase family protein	-
LP114_RS00480 (LP114_00480)	98841..99053	-	213	WP_078274724.1	hypothetical protein	-
LP114_RS00485 (LP114_00485)	99169..99993	-	825	WP_078274723.1	site-specific integrase	-
LP114_RS00490 (LP114_00490)	100043..100324	-	282	WP_078274722.1	NadS family protein	Antitoxin
LP114_RS00495 (LP114_00495)	100314..100649	-	336	WP_228157738.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LP114_RS00500 (LP114_00500)	100713..101873	-	1161	WP_078274721.1	zonular occludens toxin domain-containing protein	-
LP114_RS00505 (LP114_00505)	101959..102252	-	294	WP_078274720.1	DUF2523 family protein	-
LP114_RS00510 (LP114_00510)	102488..103123	-	636	WP_264684288.1	hypothetical protein	-
LP114_RS00515 (LP114_00515)	103616..103873	-	258	WP_112741693.1	hypothetical protein	-
LP114_RS00520 (LP114_00520)	103944..104321	+	378	WP_264684286.1	hypothetical protein	-
LP114_RS00525 (LP114_00525)	104444..104689	+	246	WP_078274709.1	hypothetical protein	-
LP114_RS00530 (LP114_00530)	104976..105251	+	276	WP_078274708.1	hypothetical protein	-
LP114_RS00535	105454..105588	-	135	WP_264676041.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (43-106)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-84)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 12636.69 Da
• Isoelectric Point: 10.0972

>T226356 WP_228157738.1 NZ_CP087848:c100649-100314 [Moraxella bovis]
MLHFAETSLFTKQIIDLMDDDEYRLLQTNLMKNPHQGDIVRGTGGVRKTRWSIDGKGKSGGSRIIYFFVDGAGIFFMLLA
YPKSKQTTLSADEKKEMLKLTTAIKEIYRAK

Nucleotide

• Length: 336 bp

>T226356 NZ_CP122451:c1921526-1921152 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTAGGTAAGTATCCGGAGGCGAAATGA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10425.98 Da
• Isoelectric Point: 10.0023

>AT226356 WP_078274722.1 NZ_CP087848:c100324-100043 [Moraxella bovis]
VQNEFYDDLKASLTEALAIAKGEISPSRTFTYERPNIKDIRAKTGLSQTQFAQKLHISPKTLKNWEQGIRTPTGPAITLI
RLLDKNPDLISMA

Nucleotide

• Length: 282 bp

>AT226356 NZ_CP122451:c1921983-1921615 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGTTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTCAGCCCCCGCTATCAGCATACCGTCACGCTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA