Detailed information of TA system TA226348

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 920973..921571
• Replicon: chromosome
• Accession: NZ_CP087844
• Organism: Moraxella bovis strain SAM58105

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: LP103_RS04905
• Protein ID: WP_078275306.1
• Coordinates: 921293..921571 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: graA
• Uniprot ID: -
• Locus tag: LP103_RS04900
• Protein ID: WP_078275307.1
• Coordinates: 920973..921278 (-)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP103_RS04865 (LP103_04835)	917494..917826	+	333	WP_078275314.1	phage tail protein	-
LP103_RS04870 (LP103_04840)	917862..918251	+	390	WP_078275313.1	hypothetical protein	-
LP103_RS04875 (LP103_04845)	918248..918931	+	684	WP_264676213.1	phage minor tail protein L	-
LP103_RS04880 (LP103_04850)	918973..919203	-	231	WP_078275311.1	Arc family DNA-binding protein	-
LP103_RS04885 (LP103_04855)	919376..919972	+	597	WP_264676214.1	antA/AntB antirepressor family protein	-
LP103_RS04890 (LP103_04860)	919969..920157	+	189	WP_078275309.1	hypothetical protein	-
LP103_RS04895 (LP103_04865)	920225..921001	+	777	WP_078275308.1	C40 family peptidase	-
LP103_RS04900 (LP103_04870)	920973..921278	-	306	WP_078275307.1	HigA family addiction module antitoxin	Antitoxin
LP103_RS04905 (LP103_04875)	921293..921571	-	279	WP_078275306.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LP103_RS04910 (LP103_04880)	921657..922241	+	585	WP_264676215.1	tail assembly protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	887009..936985	49976

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-92)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (1-95)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10491.92 Da
• Isoelectric Point: 5.0474

>T226348 WP_078275306.1 NZ_CP087844:c921571-921293 [Moraxella bovis]
MIQSFKCKDAQSLFETGSSRVFANFLSVATRKLTMLDNAVALADLRIPPANRLEKLTGDREGQYSIRINDQFRICFVWGD
DGVYDVEIVDYH

Nucleotide

• Length: 279 bp

>T226348 NZ_CP122451:178342-178449 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 11173.81 Da
• Isoelectric Point: 7.3174

>AT226348 WP_078275307.1 NZ_CP087844:c921278-920973 [Moraxella bovis]
MFKNGMRPVHAGEVLREEYLIPMGMSATALANALGVTPARINDIVRQRRGVTADTALRLARYFGGTAQFWLNLQTTYELR
LAETTLGDSLDFISPHEVAHA

Nucleotide

• Length: 306 bp

>AT226348 NZ_CP122451:c178294-178228 [Escherichia coli]
GGTCTAGGTTCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT