Detailed information of TA system TA226340

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 2264500..2265098
• Replicon: chromosome
• Accession: NZ_CP087843
• Organism: Moraxella bovis strain SAM58106

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: LP121_RS11325
• Protein ID: WP_078275306.1
• Coordinates: 2264500..2264778 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: LP121_RS11330
• Protein ID: WP_276001721.1
• Coordinates: 2264808..2265098 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP121_RS11320 (LP121_11225)	2263830..2264414	-	585	WP_264676215.1	tail assembly protein	-
LP121_RS11325 (LP121_11230)	2264500..2264778	+	279	WP_078275306.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LP121_RS11330 (LP121_11235)	2264808..2265098	+	291	WP_276001721.1	HigA family addiction module antitoxin	Antitoxin
LP121_RS11335 (LP121_11240)	2265070..2265846	-	777	WP_112742102.1	C40 family peptidase	-
LP121_RS11340 (LP121_11245)	2265914..2266102	-	189	WP_078275309.1	hypothetical protein	-
LP121_RS11345 (LP121_11250)	2266099..2266641	-	543	WP_078275310.1	antA/AntB antirepressor family protein	-
LP121_RS11350 (LP121_11255)	2266814..2267044	+	231	WP_078275311.1	Arc family DNA-binding protein	-
LP121_RS11355 (LP121_11260)	2267086..2267769	-	684	WP_078275312.1	phage minor tail protein L	-
LP121_RS11360 (LP121_11265)	2267766..2268155	-	390	WP_078275313.1	hypothetical protein	-
LP121_RS11365 (LP121_11270)	2268191..2268523	-	333	WP_078275314.1	phage tail protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2255487..2302985	47498

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-92)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (1-90)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10491.92 Da
• Isoelectric Point: 5.0474

>T226340 WP_078275306.1 NZ_CP087843:2264500-2264778 [Moraxella bovis]
MIQSFKCKDAQSLFETGSSRVFANFLSVATRKLTMLDNAVALADLRIPPANRLEKLTGDREGQYSIRINDQFRICFVWGD
DGVYDVEIVDYH

Nucleotide

• Length: 279 bp

>T226340 NZ_CP122448:4169302-4169454 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10596.11 Da
• Isoelectric Point: 6.7228

>AT226340 WP_276001721.1 NZ_CP087843:2264808-2265098 [Moraxella bovis]
MRPVHAGEVLREEYLIPMGMSATALANALGVTPARINDIVRQRRGVTADTALRLARYFGGTAQFWLNLQTTYELRLAETT
LGDSLDFISPHEVAHA

Nucleotide

• Length: 291 bp

>AT226340 NZ_CP122448:c4169253-4169196 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA