Detailed information of TA system TA226331

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 1805176..1805774
• Replicon: chromosome
• Accession: NZ_CP087840
• Organism: Moraxella bovis strain SAM58116

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: LP107_RS09030
• Protein ID: WP_078275306.1
• Coordinates: 1805176..1805454 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: graA
• Uniprot ID: -
• Locus tag: LP107_RS09035
• Protein ID: WP_078275307.1
• Coordinates: 1805469..1805774 (+)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP107_RS08995 (LP107_08905)	1800294..1800983	+	690	WP_078275398.1	ribose-5-phosphate isomerase RpiA	-
LP107_RS09000 (LP107_08910)	1801203..1802423	+	1221	WP_078275300.1	integrase arm-type DNA-binding domain-containing protein	-
LP107_RS09005 (LP107_08915)	1802477..1803019	-	543	WP_244893697.1	D-Ala-D-Ala carboxypeptidase family metallohydrolase	-
LP107_RS09010 (LP107_08920)	1803043..1803360	-	318	WP_078275302.1	phage holin family protein	-
LP107_RS09015 (LP107_08925)	1803469..1804128	-	660	WP_264682756.1	hypothetical protein	-
LP107_RS09020 (LP107_08930)	1804125..1804481	-	357	WP_264682758.1	hypothetical protein	-
LP107_RS09025 (LP107_08935)	1804506..1805090	-	585	WP_264676215.1	tail assembly protein	-
LP107_RS09030 (LP107_08940)	1805176..1805454	+	279	WP_078275306.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LP107_RS09035 (LP107_08945)	1805469..1805774	+	306	WP_078275307.1	HigA family addiction module antitoxin	Antitoxin
LP107_RS09040 (LP107_08950)	1805746..1806522	-	777	WP_078275308.1	C40 family peptidase	-
LP107_RS09045 (LP107_08955)	1806590..1806778	-	189	WP_078275309.1	hypothetical protein	-
LP107_RS09050 (LP107_08960)	1806775..1807371	-	597	WP_264676214.1	antA/AntB antirepressor family protein	-
LP107_RS09055 (LP107_08965)	1807544..1807774	+	231	WP_078275311.1	Arc family DNA-binding protein	-
LP107_RS09060 (LP107_08970)	1807816..1808499	-	684	WP_264676213.1	phage minor tail protein L	-
LP107_RS09065 (LP107_08975)	1808496..1808885	-	390	WP_078275313.1	hypothetical protein	-
LP107_RS09070 (LP107_08980)	1808921..1809253	-	333	WP_078275314.1	phage tail protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1794792..1841586	46794

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-92)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (1-95)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10491.92 Da
• Isoelectric Point: 5.0474

>T226331 WP_078275306.1 NZ_CP087840:1805176-1805454 [Moraxella bovis]
MIQSFKCKDAQSLFETGSSRVFANFLSVATRKLTMLDNAVALADLRIPPANRLEKLTGDREGQYSIRINDQFRICFVWGD
DGVYDVEIVDYH

Nucleotide

• Length: 279 bp

>T226331 NZ_CP122448:2308396-2308498 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 11173.81 Da
• Isoelectric Point: 7.3174

>AT226331 WP_078275307.1 NZ_CP087840:1805469-1805774 [Moraxella bovis]
MFKNGMRPVHAGEVLREEYLIPMGMSATALANALGVTPARINDIVRQRRGVTADTALRLARYFGGTAQFWLNLQTTYELR
LAETTLGDSLDFISPHEVAHA

Nucleotide

• Length: 306 bp

>AT226331 NZ_CP122448:c2308536-2308268 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT