Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 100035..100641 Replicon chromosome
Accession NZ_CP087840
Organism Moraxella bovis strain SAM58116

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LP107_RS00490 Protein ID WP_228157738.1
Coordinates 100306..100641 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LP107_RS00485 Protein ID WP_078274722.1
Coordinates 100035..100316 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP107_RS00460 (LP107_00465) 95733..96491 + 759 WP_078274726.1 YciK family oxidoreductase -
LP107_RS00465 (LP107_00470) 96601..97926 + 1326 WP_112741690.1 hemolysin family protein -
LP107_RS00470 (LP107_00475) 98071..98793 + 723 WP_029103568.1 nitroreductase family protein -
LP107_RS00475 (LP107_00480) 98833..99045 - 213 WP_078274724.1 hypothetical protein -
LP107_RS00480 (LP107_00485) 99161..99985 - 825 WP_078274723.1 site-specific integrase -
LP107_RS00485 (LP107_00490) 100035..100316 - 282 WP_078274722.1 NadS family protein Antitoxin
LP107_RS00490 (LP107_00495) 100306..100641 - 336 WP_228157738.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LP107_RS00495 (LP107_00500) 100705..101865 - 1161 WP_078274721.1 zonular occludens toxin domain-containing protein -
LP107_RS00500 (LP107_00505) 101951..102244 - 294 WP_078274720.1 DUF2523 family protein -
LP107_RS00505 (LP107_00510) 102241..103116 - 876 WP_162860331.1 virulence factor TspB C-terminal domain-related protein -
LP107_RS00510 (LP107_00515) 103609..103866 - 258 WP_112741693.1 hypothetical protein -
LP107_RS00515 (LP107_00520) 103985..104314 + 330 WP_264676042.1 hypothetical protein -
LP107_RS00520 (LP107_00525) 104437..104682 + 246 WP_078274709.1 hypothetical protein -
LP107_RS00525 (LP107_00530) 104969..105244 + 276 WP_078274708.1 hypothetical protein -
LP107_RS00530 (LP107_00535) 105239..105394 - 156 WP_158079680.1 hypothetical protein -
LP107_RS00535 105446..105580 - 135 WP_264676041.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-84)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12636.69 Da        Isoelectric Point: 10.0972

>T226324 WP_228157738.1 NZ_CP087840:c100641-100306 [Moraxella bovis]
MLHFAETSLFTKQIIDLMDDDEYRLLQTNLMKNPHQGDIVRGTGGVRKTRWSIDGKGKSGGSRIIYFFVDGAGIFFMLLA
YPKSKQTTLSADEKKEMLKLTTAIKEIYRAK

Download         Length: 336 bp

>T226324 NZ_CP122448:c628247-627783 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAGCCATTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10425.98 Da        Isoelectric Point: 10.0023

>AT226324 WP_078274722.1 NZ_CP087840:c100316-100035 [Moraxella bovis]
VQNEFYDDLKASLTEALAIAKGEISPSRTFTYERPNIKDIRAKTGLSQTQFAQKLHISPKTLKNWEQGIRTPTGPAITLI
RLLDKNPDLISMA

Download         Length: 282 bp

>AT226324 NZ_CP122448:c628582-628247 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACTATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References