Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1792553..1793151 Replicon chromosome
Accession NZ_CP087837
Organism Moraxella bovis strain SAM68509

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LP086_RS08940 Protein ID WP_078275306.1
Coordinates 1792553..1792831 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag LP086_RS08945 Protein ID WP_078275307.1
Coordinates 1792846..1793151 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP086_RS08905 (LP086_08820) 1787581..1787889 + 309 WP_078275399.1 type II toxin-antitoxin system RelE/ParE family toxin -
LP086_RS08910 (LP086_08825) 1787997..1788686 + 690 WP_078275398.1 ribose-5-phosphate isomerase RpiA -
LP086_RS08915 (LP086_08830) 1788906..1790126 + 1221 WP_078275300.1 integrase arm-type DNA-binding domain-containing protein -
LP086_RS08920 (LP086_08835) 1790180..1790722 - 543 WP_244893697.1 D-Ala-D-Ala carboxypeptidase family metallohydrolase -
LP086_RS08925 (LP086_08840) 1790746..1791063 - 318 WP_078275302.1 phage holin family protein -
LP086_RS08930 (LP086_08845) 1791172..1792266 - 1095 WP_264676217.1 hypothetical protein -
LP086_RS08935 (LP086_08850) 1792309..1792467 - 159 WP_264676710.1 hypothetical protein -
LP086_RS08940 (LP086_08855) 1792553..1792831 + 279 WP_078275306.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LP086_RS08945 (LP086_08860) 1792846..1793151 + 306 WP_078275307.1 HigA family addiction module antitoxin Antitoxin
LP086_RS08950 (LP086_08865) 1793123..1793899 - 777 WP_078275308.1 C40 family peptidase -
LP086_RS08955 (LP086_08870) 1793967..1794155 - 189 WP_078275309.1 hypothetical protein -
LP086_RS08960 (LP086_08875) 1794152..1794748 - 597 WP_264676214.1 antA/AntB antirepressor family protein -
LP086_RS08965 (LP086_08880) 1794921..1795151 + 231 WP_078275311.1 Arc family DNA-binding protein -
LP086_RS08970 (LP086_08885) 1795193..1795876 - 684 WP_078275312.1 phage minor tail protein L -
LP086_RS08975 (LP086_08890) 1795873..1796262 - 390 WP_078275313.1 hypothetical protein -
LP086_RS08980 (LP086_08895) 1796298..1796630 - 333 WP_078275314.1 phage tail protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1788873..1832062 43189


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-95)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10491.92 Da        Isoelectric Point: 5.0474

>T226320 WP_078275306.1 NZ_CP087837:1792553-1792831 [Moraxella bovis]
MIQSFKCKDAQSLFETGSSRVFANFLSVATRKLTMLDNAVALADLRIPPANRLEKLTGDREGQYSIRINDQFRICFVWGD
DGVYDVEIVDYH

Download         Length: 279 bp

>T226320 NZ_CP122443:c39032-38616 [Enterobacter ludwigii]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGTGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCT
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACCGCCATTGC
CGGACACGCCATCGCGGCGGGCGCCATCCTGGTGACGAATAATACAAGAGAGTTTGAGCGGGTGCCGGGTCTGGTTCTGG
AAGACTGGGTTAAGTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11173.81 Da        Isoelectric Point: 7.3174

>AT226320 WP_078275307.1 NZ_CP087837:1792846-1793151 [Moraxella bovis]
MFKNGMRPVHAGEVLREEYLIPMGMSATALANALGVTPARINDIVRQRRGVTADTALRLARYFGGTAQFWLNLQTTYELR
LAETTLGDSLDFISPHEVAHA

Download         Length: 306 bp

>AT226320 NZ_CP122443:c39259-39029 [Enterobacter ludwigii]
ATGCGCACAGTATCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTAG
ACAGGGCCGATCCGGACTTTATGGCGCAGCGTGAGGATGTGGTCAGCGACGAAGGACGCTTTGATCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References