Detailed information of TA system TA226313

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 100325..100931
• Replicon: chromosome
• Accession: NZ_CP087837
• Organism: Moraxella bovis strain SAM68509

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: LP086_RS00490
• Protein ID: WP_228157738.1
• Coordinates: 100596..100931 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: LP086_RS00485
• Protein ID: WP_078274722.1
• Coordinates: 100325..100606 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP086_RS00460 (LP086_00465)	96023..96781	+	759	WP_078274726.1	YciK family oxidoreductase	-
LP086_RS00465 (LP086_00470)	96891..98216	+	1326	WP_112741690.1	hemolysin family protein	-
LP086_RS00470 (LP086_00475)	98361..99083	+	723	WP_029103568.1	nitroreductase family protein	-
LP086_RS00475 (LP086_00480)	99123..99335	-	213	WP_264676739.1	hypothetical protein	-
LP086_RS00480 (LP086_00485)	99451..100275	-	825	WP_078274723.1	site-specific integrase	-
LP086_RS00485 (LP086_00490)	100325..100606	-	282	WP_078274722.1	NadS family protein	Antitoxin
LP086_RS00490 (LP086_00495)	100596..100931	-	336	WP_228157738.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LP086_RS00495 (LP086_00500)	100995..102155	-	1161	WP_078274721.1	zonular occludens toxin domain-containing protein	-
LP086_RS00500 (LP086_00505)	102241..102534	-	294	WP_078274720.1	DUF2523 family protein	-
LP086_RS00505 (LP086_00510)	102531..103406	-	876	WP_162860331.1	virulence factor TspB C-terminal domain-related protein	-
LP086_RS00510 (LP086_00515)	103899..104156	-	258	WP_112741693.1	hypothetical protein	-
LP086_RS00515 (LP086_00520)	104275..104604	+	330	WP_264676042.1	hypothetical protein	-
LP086_RS00520 (LP086_00525)	104727..104972	+	246	WP_078274709.1	hypothetical protein	-
LP086_RS00525 (LP086_00530)	105259..105534	+	276	WP_078274708.1	hypothetical protein	-
LP086_RS00530 (LP086_00535)	105529..105684	-	156	WP_158079680.1	hypothetical protein	-
LP086_RS00535	105736..105870	-	135	WP_264676041.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (43-106)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-84)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 12636.69 Da
• Isoelectric Point: 10.0972

>T226313 WP_228157738.1 NZ_CP087837:c100931-100596 [Moraxella bovis]
MLHFAETSLFTKQIIDLMDDDEYRLLQTNLMKNPHQGDIVRGTGGVRKTRWSIDGKGKSGGSRIIYFFVDGAGIFFMLLA
YPKSKQTTLSADEKKEMLKLTTAIKEIYRAK

Nucleotide

• Length: 336 bp

>T226313 NZ_CP122442:101076-101486 [Enterobacter ludwigii]
GTGGTCCTGTGGCAATCTGACCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCGTTGTTGCTCCACGGACTGGTCGCGGC
CTTTGTGTTACTGATGCCGTGGCCGCTTAGCTATACGCCTCTGTGGCTGCTGTTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGCCGCATTCATGCCCGTCAGGGGGAGATCAAATTACTGATGGATTCCCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAAATTCTCGGTATGCCCTGGATGATCGCTTCCGGCATGATGCTGCGGCTACGTAGCGTGGACAGCGGGCGTCG
CCAGCATCTGTGGCTGGCCGCGGACAGTATGGATAGCGCTGAGTGGCGGGACCTGCGTCGGATGTTATTACAGCAGCTGA
CGCAGGAGTAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10425.98 Da
• Isoelectric Point: 10.0023

>AT226313 WP_078274722.1 NZ_CP087837:c100606-100325 [Moraxella bovis]
VQNEFYDDLKASLTEALAIAKGEISPSRTFTYERPNIKDIRAKTGLSQTQFAQKLHISPKTLKNWEQGIRTPTGPAITLI
RLLDKNPDLISMA

Nucleotide

• Length: 282 bp

>AT226313 NZ_CP122442:100829-101095 [Enterobacter ludwigii]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACAGCTTAAGCGATGATGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCTGATT
TATTTAACTGGCTGATGAATCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA