Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2851949..2852555 Replicon chromosome
Accession NZ_CP087830
Organism Moraxella bovis strain SAM102599

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LP092_RS14565 Protein ID WP_228157738.1
Coordinates 2851949..2852284 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LP092_RS14570 Protein ID WP_078274722.1
Coordinates 2852274..2852555 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP092_RS14520 2847010..2847144 + 135 WP_264676041.1 hypothetical protein -
LP092_RS14525 (LP092_14390) 2847196..2847351 + 156 WP_158079680.1 hypothetical protein -
LP092_RS14530 (LP092_14395) 2847346..2847621 - 276 WP_078274708.1 hypothetical protein -
LP092_RS14535 (LP092_14400) 2847908..2848153 - 246 WP_078274709.1 hypothetical protein -
LP092_RS14540 (LP092_14405) 2848276..2848605 - 330 WP_264676042.1 hypothetical protein -
LP092_RS14545 (LP092_14410) 2848613..2848981 + 369 WP_264683399.1 hypothetical protein -
LP092_RS14550 (LP092_14415) 2849474..2850349 + 876 WP_162860331.1 virulence factor TspB C-terminal domain-related protein -
LP092_RS14555 (LP092_14420) 2850346..2850639 + 294 WP_078274720.1 DUF2523 family protein -
LP092_RS14560 (LP092_14425) 2850725..2851885 + 1161 WP_078274721.1 zonular occludens toxin domain-containing protein -
LP092_RS14565 (LP092_14430) 2851949..2852284 + 336 WP_228157738.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LP092_RS14570 (LP092_14435) 2852274..2852555 + 282 WP_078274722.1 NadS family protein Antitoxin
LP092_RS14575 (LP092_14440) 2852605..2853429 + 825 WP_078274723.1 site-specific integrase -
LP092_RS14580 (LP092_14445) 2853545..2853757 + 213 WP_078274724.1 hypothetical protein -
LP092_RS14585 (LP092_14450) 2853797..2854519 - 723 WP_029103568.1 nitroreductase family protein -
LP092_RS14590 (LP092_14455) 2854664..2855989 - 1326 WP_112741690.1 hemolysin family protein -
LP092_RS14595 (LP092_14460) 2856099..2856857 - 759 WP_078274726.1 YciK family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-84)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12636.69 Da        Isoelectric Point: 10.0972

>T226311 WP_228157738.1 NZ_CP087830:2851949-2852284 [Moraxella bovis]
MLHFAETSLFTKQIIDLMDDDEYRLLQTNLMKNPHQGDIVRGTGGVRKTRWSIDGKGKSGGSRIIYFFVDGAGIFFMLLA
YPKSKQTTLSADEKKEMLKLTTAIKEIYRAK

Download         Length: 336 bp

>T226311 NZ_CP122407:c5349408-5348938 [Rugamonas sp. DEMB1]
ATGACGGTCAGCGCATGGCGCATCGCGGTCGAGGCACCGGGCTATTCGGCCAGCGACCTGAGCGGTGCCGGGGCGAAGCG
CAGCGGCGGCAGGTGGAATGCCCGCCGCACGGCGATGGTCTATTGTTCTTCCAATATTGCGCTGGCCATGCTGGAAACCC
TGAGCTTTGTACGCACGGGATCCCTGCCATTCAACCGCTTCCTCGTAAGAATCGACATTCCCGACCTCGTTTGGGGGCGA
CGCGAAGTCCTCGCGCCGGTGCCGGGCGGCTGGGATGCGGTGCCGGCGGGCCGAGCCAGCATGGCGGCGGGAGATGCCTG
GGCATTCAGTCGGCGCTCGGCGCTGCTGCTGGTGCCGTCGGTCATCGTGCCGGAGGAGTTTAATATCTTGCTGAACCCAA
CCCATTCCGATGCTGCCGCGATTGCGGCGACGACGGTGAGGCGCTGGGTGTACGATCCTCGATTCTTTTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10425.98 Da        Isoelectric Point: 10.0023

>AT226311 WP_078274722.1 NZ_CP087830:2852274-2852555 [Moraxella bovis]
VQNEFYDDLKASLTEALAIAKGEISPSRTFTYERPNIKDIRAKTGLSQTQFAQKLHISPKTLKNWEQGIRTPTGPAITLI
RLLDKNPDLISMA

Download         Length: 282 bp

>AT226311 NZ_CP122407:c5349836-5349405 [Rugamonas sp. DEMB1]
GTGAAAATCGTCGACGACAACGTTTATCTGATGAATGCGGCGGACCGCATCGAGCTGATCCGGAGCGGCGTGCCGGCGGC
GCACTTGGCCGTGTTGTCCGTCAAAATGGGCATGCCAGAGGGGCGCTTGCTGGCGCTGCTGGGCATGTCGCGCGCCACGG
TCAGCCGCAAGGTGCGGGAACATCAGCCTCTGGCCCCGGAGGAATCCGAGCGCGTGCTGGGCGTCGAATCGCTGATCGGG
CAGGTTGACGCCATGGTGCGTGAATCGGGCGAGCCGGTCGGTTTCGATGCGGCGCGGTGGCTTGCCGACTGGCTAGCCAT
GCCAGTGCCCGCGCTCAACGGCCGCACCCCGGCCAGCTACCTGGACACCATCGAGGGGCAGAAACTGCTTTCCGATCTGT
TGGCAATGGCGCAAAGCGGCGCCTACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References