Detailed information of TA system TA226298

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 1821424..1822022
• Replicon: chromosome
• Accession: NZ_CP087828
• Organism: Moraxella bovis strain SAM102600

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: LP099_RS09085
• Protein ID: WP_078275306.1
• Coordinates: 1821424..1821702 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: graA
• Uniprot ID: -
• Locus tag: LP099_RS09090
• Protein ID: WP_078275307.1
• Coordinates: 1821717..1822022 (+)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP099_RS09080 (LP099_08995)	1820754..1821338	-	585	WP_264676215.1	tail assembly protein	-
LP099_RS09085 (LP099_09000)	1821424..1821702	+	279	WP_078275306.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LP099_RS09090 (LP099_09005)	1821717..1822022	+	306	WP_078275307.1	HigA family addiction module antitoxin	Antitoxin
LP099_RS09095 (LP099_09010)	1821994..1822770	-	777	WP_112742102.1	C40 family peptidase	-
LP099_RS09100 (LP099_09015)	1822838..1823026	-	189	WP_078275309.1	hypothetical protein	-
LP099_RS09105 (LP099_09020)	1823023..1823619	-	597	WP_264676214.1	antA/AntB antirepressor family protein	-
LP099_RS09110 (LP099_09025)	1823792..1824022	+	231	WP_078275311.1	Arc family DNA-binding protein	-
LP099_RS09115 (LP099_09030)	1824064..1824747	-	684	WP_264676213.1	phage minor tail protein L	-
LP099_RS09120 (LP099_09035)	1824744..1825133	-	390	WP_078275313.1	hypothetical protein	-
LP099_RS09125 (LP099_09040)	1825169..1825501	-	333	WP_078275314.1	phage tail protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1815778..1859873	44095

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-92)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (1-95)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10491.92 Da
• Isoelectric Point: 5.0474

>T226298 WP_078275306.1 NZ_CP087828:1821424-1821702 [Moraxella bovis]
MIQSFKCKDAQSLFETGSSRVFANFLSVATRKLTMLDNAVALADLRIPPANRLEKLTGDREGQYSIRINDQFRICFVWGD
DGVYDVEIVDYH

Nucleotide

• Length: 279 bp

>T226298 NZ_CP122401:4016559-4016969 [Enterobacter roggenkampii]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCTTTATTGCTCCACGGCCTGGTTGCGGC
CATTGTGTTACTGATGCCGTGGCCGCTGAGCTATACGCCGCTGTGGCTGCTGTTACTGTCGTTTGTCGTTTTTGACAGCG
TACGCAGCCAGCGTCGTATTAATGCCCGTCAGGGAGAGATTAAATTACTGATGGATTCCCGCCTGCGCTGGCAGGGAAAA
GAGTGGGATATTCTCGGGATGCCCTGGATGCTCAACTGCGGCATGATGTTACGGTTACGCAAGGTGGACGGCGGGCGTTG
CCAGCATCTTTGGCTGGCGGCTGACAGTATGGATGCTGCCGAGTGGCGAGACCTGCGCCGGATGCTGTTGCAACAGACGA
CGCAGGGGTAA

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 11173.81 Da
• Isoelectric Point: 7.3174

>AT226298 WP_078275307.1 NZ_CP087828:1821717-1822022 [Moraxella bovis]
MFKNGMRPVHAGEVLREEYLIPMGMSATALANALGVTPARINDIVRQRRGVTADTALRLARYFGGTAQFWLNLQTTYELR
LAETTLGDSLDFISPHEVAHA

Nucleotide

• Length: 306 bp

>AT226298 NZ_CP122401:4016312-4016578 [Enterobacter roggenkampii]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACACCTTAAGCGACGACGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAACCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA