Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 100237..100843 Replicon chromosome
Accession NZ_CP087828
Organism Moraxella bovis strain SAM102600

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LP099_RS00485 Protein ID WP_228157738.1
Coordinates 100508..100843 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LP099_RS00480 Protein ID WP_078274722.1
Coordinates 100237..100518 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP099_RS00455 (LP099_00460) 95935..96693 + 759 WP_078274726.1 YciK family oxidoreductase -
LP099_RS00460 (LP099_00465) 96803..98128 + 1326 WP_112741690.1 hemolysin family protein -
LP099_RS00465 (LP099_00470) 98273..98995 + 723 WP_029103568.1 nitroreductase family protein -
LP099_RS00470 (LP099_00475) 99035..99247 - 213 WP_078274724.1 hypothetical protein -
LP099_RS00475 (LP099_00480) 99363..100187 - 825 WP_078274723.1 site-specific integrase -
LP099_RS00480 (LP099_00485) 100237..100518 - 282 WP_078274722.1 NadS family protein Antitoxin
LP099_RS00485 (LP099_00490) 100508..100843 - 336 WP_228157738.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LP099_RS00490 (LP099_00495) 100907..102067 - 1161 WP_078274721.1 zonular occludens toxin domain-containing protein -
LP099_RS00495 (LP099_00500) 102153..102446 - 294 WP_078274720.1 DUF2523 family protein -
LP099_RS00500 (LP099_00505) 102443..102784 - 342 WP_143821706.1 virulence factor TspB C-terminal domain-related protein -
LP099_RS00505 (LP099_00510) 102789..102965 + 177 WP_264690249.1 hypothetical protein -
LP099_RS00510 (LP099_00515) 103189..104481 - 1293 WP_112741696.1 beta-ketoacyl-ACP synthase II -
LP099_RS00515 (LP099_00520) 104621..105490 - 870 WP_078274702.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-84)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12636.69 Da        Isoelectric Point: 10.0972

>T226293 WP_228157738.1 NZ_CP087828:c100843-100508 [Moraxella bovis]
MLHFAETSLFTKQIIDLMDDDEYRLLQTNLMKNPHQGDIVRGTGGVRKTRWSIDGKGKSGGSRIIYFFVDGAGIFFMLLA
YPKSKQTTLSADEKKEMLKLTTAIKEIYRAK

Download         Length: 336 bp

>T226293 NZ_CP122397:267357-267707 [Rossellomorea sp. DA94]
TTGATTGTAAAGCGTGGTGACGTATATTTTGCAGACCTTTCTCCTGTTGTAGGTTCAGAACAAGGCGGAGTTCGGCCGGT
ACTTGTTATTCAAAACGATATAGGGAACAGGTTTAGTCCCACAATTATTGTAGCTGCCATTACCGCACAAATTCAAAAAG
CAAAACTGCCTACTCATGTTGAAATTGATGCAAAACGTTATGGCTTTGAACGTGATTCCGTTATCTTGCTTGAACAGATT
CGAACGATTGATAAACAACGTCTTACCGATAAGATCACACACTTGGATGACGAGATGATGGAGAAAGTGGACGACGCCCT
GCAAATCAGTGTGGGTCTGATCCAGTTTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10425.98 Da        Isoelectric Point: 10.0023

>AT226293 WP_078274722.1 NZ_CP087828:c100518-100237 [Moraxella bovis]
VQNEFYDDLKASLTEALAIAKGEISPSRTFTYERPNIKDIRAKTGLSQTQFAQKLHISPKTLKNWEQGIRTPTGPAITLI
RLLDKNPDLISMA

Download         Length: 282 bp

>AT226293 NZ_CP122397:267071-267352 [Rossellomorea sp. DA94]
GTGTCTGAATCCAGCGCAACAACAGAAATCTTAATTCGTCTACCGCAACAGCTCGTTACAGAATTGGACGGCTTTGCAGA
TCAAGAAAATGTGAATCGCAATGAGTTTATTTATCGTGCAACCAAAATGTATTTACGAGAGCGTAAGAAGAGACAATTAC
GTGAATCTATGAGACGCGGCTATATGGAAATGGCGAAGATTAATCTCGCGATCGCTTCAGAAGCGATTCAAGCAGAATAT
GAGGCAGAACATACAGTCGAACGCTTAGTAAGCGGAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References