Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2439791..2440397 Replicon chromosome
Accession NZ_CP087825
Organism Moraxella bovis strain SAM102601

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LP108_RS12375 Protein ID WP_228157738.1
Coordinates 2440062..2440397 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LP108_RS12370 Protein ID WP_078274722.1
Coordinates 2439791..2440072 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP108_RS12345 (LP108_12220) 2435489..2436247 + 759 WP_078274726.1 YciK family oxidoreductase -
LP108_RS12350 (LP108_12225) 2436357..2437682 + 1326 WP_112741690.1 hemolysin family protein -
LP108_RS12355 (LP108_12230) 2437827..2438549 + 723 WP_029103568.1 nitroreductase family protein -
LP108_RS12360 (LP108_12235) 2438589..2438801 - 213 WP_078274724.1 hypothetical protein -
LP108_RS12365 (LP108_12240) 2438917..2439741 - 825 WP_078274723.1 site-specific integrase -
LP108_RS12370 (LP108_12245) 2439791..2440072 - 282 WP_078274722.1 NadS family protein Antitoxin
LP108_RS12375 (LP108_12250) 2440062..2440397 - 336 WP_228157738.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LP108_RS12380 (LP108_12255) 2440461..2441621 - 1161 WP_078274721.1 zonular occludens toxin domain-containing protein -
LP108_RS12385 (LP108_12260) 2441707..2442000 - 294 WP_078274720.1 DUF2523 family protein -
LP108_RS12390 (LP108_12265) 2441997..2442872 - 876 WP_162860331.1 virulence factor TspB C-terminal domain-related protein -
LP108_RS12395 (LP108_12270) 2443365..2443733 - 369 WP_264683399.1 hypothetical protein -
LP108_RS12400 (LP108_12275) 2443741..2444070 + 330 WP_264676042.1 hypothetical protein -
LP108_RS12405 (LP108_12280) 2444193..2444438 + 246 WP_078274709.1 hypothetical protein -
LP108_RS12410 (LP108_12285) 2444725..2445000 + 276 WP_078274708.1 hypothetical protein -
LP108_RS12415 (LP108_12290) 2444995..2445150 - 156 WP_158079680.1 hypothetical protein -
LP108_RS12420 2445202..2445336 - 135 WP_264676041.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-84)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12636.69 Da        Isoelectric Point: 10.0972

>T226290 WP_228157738.1 NZ_CP087825:c2440397-2440062 [Moraxella bovis]
MLHFAETSLFTKQIIDLMDDDEYRLLQTNLMKNPHQGDIVRGTGGVRKTRWSIDGKGKSGGSRIIYFFVDGAGIFFMLLA
YPKSKQTTLSADEKKEMLKLTTAIKEIYRAK

Download         Length: 336 bp

>T226290 NZ_CP122390:c151623-150298 [Klebsiella pneumoniae]
ATGAGCCGGAAACAGCAACGTCTGGTAATTTGGATGAACGGCATCAAAGTCGGGTACTGGGAAAAAAGCAAAGGGGTAGA
CAGCTTAGAATACCTTCCTGAATGGGTTGCTGACGAACAGGGAAGGCCGCTGTCATTGTCCCTTCCTTTTACTCCCGGGA
ACCAGGTCTGGCGTGGAAATGTGGTACGTGACTATTTTGATAATTTACTGCCGGACAGCGAAGGCATACGCAGACGTCTG
GCAATGCGTTACAAGGCCGATAGCCTGGAGCCTTTTGATCTGCTGACGGAGCTGGGAAAAGACTGCGTGGGCGCGATACA
GCTGCTTCATGACGGAGATGAACCCACTGATTTATATTCCGTGAAGTATCACCCGCTTACTGAATCAGAAATTGCGGCAA
CTTTGCGTAATACCACGGAGACATTGCTACCGGGCAGGCCAGAAGATAACGACGACTTACGTTTATCTATTGCCGGTGCT
CAGGAGAAAACAGCCCTACTGTGGCATGAAGATCGGTGGTGTATGCCGGAGGGTAATACACCAACGACGCATATATTCAA
GCTACCGCTCGGACTTGTGGGGAACATGAAAGCCGACATGAGCTCGTCGGTTGAAAATGAATGGCTCTGCTCGGTACTTC
TCGGCCAGTACGGGCTCCCCGTGGCAAGAACGCAGATTGCTCACTTTGAAGATCAGAAAGCGCTGGTGGTAGAACGTTTT
GACCGAAAATGGTCAGGAGACGGACAATGGATCATTCGTTTACCCCAGGAGGATATGTGTCAGGCCCTGGGCGTTTCGCC
ATTACGAAAATATCAGGCGGACGGCGGGCCAGGTATATCGGAAATTATGGAGGTTCTGAGTAATTCAGACCGTGCTGAGC
GTGACAAAGCGCAGTTTTTTATGACGCAGATAATTTTCTGGATGATGGCCGCAACAGATGGCCACGCTAAAAATTTCAGT
ATTTCTATTGGGCCACAGGGACGTTATCACCTTACACCAAACTATGATGTGTTGTCGGCATGGCCGGTGATCGGTCATGG
GAACAATCAGATATCCTGGCAGAAGTGCAAACTGGCGATGGCCGTACGTGGCAGTAGCAACTATTACCAGATATATCGAA
TACAACGACGCCACTGGATCAGGCATGGTGAGATAACCGGCCTGAGTAAACAGCAGACAGAGGCGATGATAGAGGAAATC
ATCGCCAGAACCCCGGGTGTCATTGAACGTGTTAGCGGGCTTCTTCCGGACCAGTTCCCCCAGCAGCTTGCGGAAAGTAT
TTTTGATGGAATGAGGCAGCAATGCAGGCGCCTGGCTGAGAAATGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10425.98 Da        Isoelectric Point: 10.0023

>AT226290 WP_078274722.1 NZ_CP087825:c2440072-2439791 [Moraxella bovis]
VQNEFYDDLKASLTEALAIAKGEISPSRTFTYERPNIKDIRAKTGLSQTQFAQKLHISPKTLKNWEQGIRTPTGPAITLI
RLLDKNPDLISMA

Download         Length: 282 bp

>AT226290 NZ_CP122390:c151921-151628 [Klebsiella pneumoniae]
ATCAATAATGATTACCCGTTAAACACGCTCAACCAGCTGCGTCCCTTGCTCATTGGTTTTCGCAAGGCGAATGGCCTGAC
GCAAAAAGACCTGTCCGAAAGGTTAGGCGTCACTCAACAGACATACTCACGTCTGGAAGCCAACCCTGCCAGTGCGAGCA
TTGAACGGCTATTCAAGGTGTTTTCCATCCTGGGCGTAAAAATCAGCTTCTCCTCGGCAACCACCTCTTCAGAGAGGAAG
CAGACGGAAGAAATGCTTAAATCAAACTCACCTGCACGACAGGAGGATTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References