Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1345968..1346566 Replicon chromosome
Accession NZ_CP087825
Organism Moraxella bovis strain SAM102601

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LP108_RS06690 Protein ID WP_078275306.1
Coordinates 1345968..1346246 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag LP108_RS06695 Protein ID WP_078275307.1
Coordinates 1346261..1346566 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP108_RS06685 (LP108_06605) 1345298..1345882 - 585 WP_264676215.1 tail assembly protein -
LP108_RS06690 (LP108_06610) 1345968..1346246 + 279 WP_078275306.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LP108_RS06695 (LP108_06615) 1346261..1346566 + 306 WP_078275307.1 HigA family addiction module antitoxin Antitoxin
LP108_RS06700 (LP108_06620) 1346538..1347314 - 777 WP_078275308.1 C40 family peptidase -
LP108_RS06705 (LP108_06625) 1347382..1347570 - 189 WP_078275309.1 hypothetical protein -
LP108_RS06710 (LP108_06630) 1347567..1348163 - 597 WP_264676214.1 antA/AntB antirepressor family protein -
LP108_RS06715 (LP108_06635) 1348336..1348566 + 231 WP_078275311.1 Arc family DNA-binding protein -
LP108_RS06720 (LP108_06640) 1348608..1349291 - 684 WP_264676213.1 phage minor tail protein L -
LP108_RS06725 (LP108_06645) 1349288..1349677 - 390 WP_078275313.1 hypothetical protein -
LP108_RS06730 (LP108_06650) 1349713..1350045 - 333 WP_078275314.1 phage tail protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1336932..1385489 48557


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-95)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10491.92 Da        Isoelectric Point: 5.0474

>T226286 WP_078275306.1 NZ_CP087825:1345968-1346246 [Moraxella bovis]
MIQSFKCKDAQSLFETGSSRVFANFLSVATRKLTMLDNAVALADLRIPPANRLEKLTGDREGQYSIRINDQFRICFVWGD
DGVYDVEIVDYH

Download         Length: 279 bp

>T226286 NZ_CP122389:c4742667-4742335 [Klebsiella pneumoniae]
ATGAAAACTTTACCTGCAACAACTCCGCAGACGGCGAAGCTATGTCTGACGTCCGCGGATACCTGGCAAATGTTACTGAC
ACGTCTGCTAGAACAGCATTATGGCCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTTATTAAGGAACATATTG
ATGCAGGGATCCCTCTGGCCGATGCAGTTAACTTTCTGGTGGATAAGTACGCACTGGTTCGTATCGATCGCAGAGGATTG
AGTTGGCAGGAGCAATCATCCTATCTCCGGCTTGTCGATACTCAGCGAACCATTAAGGTTATTGAGTTGTGGCTATTTGG
TGTAATGATGTAG

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11173.81 Da        Isoelectric Point: 7.3174

>AT226286 WP_078275307.1 NZ_CP087825:1346261-1346566 [Moraxella bovis]
MFKNGMRPVHAGEVLREEYLIPMGMSATALANALGVTPARINDIVRQRRGVTADTALRLARYFGGTAQFWLNLQTTYELR
LAETTLGDSLDFISPHEVAHA

Download         Length: 306 bp

>AT226286 NZ_CP122389:c4743005-4742688 [Klebsiella pneumoniae]
ATGAGCAACATCACTTGGGGCCTGCAGCGGGATATCACGCCGTGCCTGGGATCACGTCTGGTGCAGGAGGGCAACCGGCT
GCACTATCTGGCTGACCGAGCAAGTATCACCGGTAAGTTTAGTGATGCCGAAAGCCTGAAGTTGGATGTCGTATTTCCAC
ATTTTATCAGTCAGATGGAATCGATGTTGACCACTGGTGAAATGAACCCTCGCCATGCCCACTGTGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACTCTTGGTAGTTCCGGCTACGTATACATCGCTGTTTATCTCACCCAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References