Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2737381..2737987 Replicon chromosome
Accession NZ_CP087823
Organism Moraxella bovis strain SAM102602

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LP123_RS13945 Protein ID WP_228157738.1
Coordinates 2737381..2737716 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LP123_RS13950 Protein ID WP_078274722.1
Coordinates 2737706..2737987 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP123_RS13915 (LP123_13780) 2732734..2733603 + 870 WP_078274702.1 helix-turn-helix domain-containing protein -
LP123_RS13920 (LP123_13785) 2733743..2735035 + 1293 WP_112741696.1 beta-ketoacyl-ACP synthase II -
LP123_RS13925 (LP123_13790) 2735259..2735435 - 177 WP_264690249.1 hypothetical protein -
LP123_RS13930 (LP123_13795) 2735440..2735781 + 342 WP_143821706.1 virulence factor TspB C-terminal domain-related protein -
LP123_RS13935 (LP123_13800) 2735778..2736071 + 294 WP_078274720.1 DUF2523 family protein -
LP123_RS13940 (LP123_13805) 2736157..2737317 + 1161 WP_078274721.1 zonular occludens toxin domain-containing protein -
LP123_RS13945 (LP123_13810) 2737381..2737716 + 336 WP_228157738.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LP123_RS13950 (LP123_13815) 2737706..2737987 + 282 WP_078274722.1 NadS family protein Antitoxin
LP123_RS13955 (LP123_13820) 2738037..2738861 + 825 WP_078274723.1 site-specific integrase -
LP123_RS13960 (LP123_13825) 2738977..2739189 + 213 WP_078274724.1 hypothetical protein -
LP123_RS13965 (LP123_13830) 2739229..2739951 - 723 WP_029103568.1 nitroreductase family protein -
LP123_RS13970 (LP123_13835) 2740096..2741421 - 1326 WP_112741690.1 hemolysin family protein -
LP123_RS13975 (LP123_13840) 2741531..2742289 - 759 WP_078274726.1 YciK family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-84)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12636.69 Da        Isoelectric Point: 10.0972

>T226281 WP_228157738.1 NZ_CP087823:2737381-2737716 [Moraxella bovis]
MLHFAETSLFTKQIIDLMDDDEYRLLQTNLMKNPHQGDIVRGTGGVRKTRWSIDGKGKSGGSRIIYFFVDGAGIFFMLLA
YPKSKQTTLSADEKKEMLKLTTAIKEIYRAK

Download         Length: 336 bp

>T226281 NZ_CP122389:2070044-2070146 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10425.98 Da        Isoelectric Point: 10.0023

>AT226281 WP_078274722.1 NZ_CP087823:2737706-2737987 [Moraxella bovis]
VQNEFYDDLKASLTEALAIAKGEISPSRTFTYERPNIKDIRAKTGLSQTQFAQKLHISPKTLKNWEQGIRTPTGPAITLI
RLLDKNPDLISMA

Download         Length: 282 bp

>AT226281 NZ_CP122389:c2070153-2070008 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References