Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1015932..1016530 Replicon chromosome
Accession NZ_CP087823
Organism Moraxella bovis strain SAM102602

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LP123_RS05345 Protein ID WP_078275306.1
Coordinates 1016252..1016530 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag LP123_RS05340 Protein ID WP_078275307.1
Coordinates 1015932..1016237 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP123_RS05305 (LP123_05270) 1012453..1012785 + 333 WP_078275314.1 phage tail protein -
LP123_RS05310 (LP123_05275) 1012821..1013210 + 390 WP_078275313.1 hypothetical protein -
LP123_RS05315 (LP123_05280) 1013207..1013890 + 684 WP_264676213.1 phage minor tail protein L -
LP123_RS05320 (LP123_05285) 1013932..1014162 - 231 WP_078275311.1 Arc family DNA-binding protein -
LP123_RS05325 (LP123_05290) 1014335..1014931 + 597 WP_264676214.1 antA/AntB antirepressor family protein -
LP123_RS05330 (LP123_05295) 1014928..1015116 + 189 WP_078275309.1 hypothetical protein -
LP123_RS05335 (LP123_05300) 1015184..1015960 + 777 WP_112742102.1 C40 family peptidase -
LP123_RS05340 (LP123_05305) 1015932..1016237 - 306 WP_078275307.1 HigA family addiction module antitoxin Antitoxin
LP123_RS05345 (LP123_05310) 1016252..1016530 - 279 WP_078275306.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LP123_RS05350 (LP123_05315) 1016616..1017200 + 585 WP_264676215.1 tail assembly protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 977735..1025533 47798


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-95)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10491.92 Da        Isoelectric Point: 5.0474

>T226276 WP_078275306.1 NZ_CP087823:c1016530-1016252 [Moraxella bovis]
MIQSFKCKDAQSLFETGSSRVFANFLSVATRKLTMLDNAVALADLRIPPANRLEKLTGDREGQYSIRINDQFRICFVWGD
DGVYDVEIVDYH

Download         Length: 279 bp

>T226276 NZ_CP122379:3188245-3188529 [Aequorivita sp. Ant34-E75]
ATGGAAACCACTAAATTTGACATAGCGGACTATTTGGACAGCGAAGACATGATTGCTGAATATCTCAATACAGTTCTCGA
AGATGGAGACAGTGCTGATTTGATAGTAGCGATCGGGCATATTGCAAAGTCAATCGGAATGACCAAAATTGCGGAGAAAA
CTGGAATGAGCAGACCAAGTCTATACAAAGCATTATCCGATGGGGCGAAACCACAATTTGGAACAATAATGAAGGTGCTG
AAAGCCATTGGTGGTCAAATCAACGTGAAACCAATATCAGCGTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11173.81 Da        Isoelectric Point: 7.3174

>AT226276 WP_078275307.1 NZ_CP087823:c1016237-1015932 [Moraxella bovis]
MFKNGMRPVHAGEVLREEYLIPMGMSATALANALGVTPARINDIVRQRRGVTADTALRLARYFGGTAQFWLNLQTTYELR
LAETTLGDSLDFISPHEVAHA

Download         Length: 306 bp

>AT226276 NZ_CP122379:3187941-3188243 [Aequorivita sp. Ant34-E75]
ATGATAATTACCGAAAAAACATCTGAATTCGATAAGTGGATTAGAAAGCTAAAAGACATTCGGGCAAAATCTAAAATACT
TTTCCGAATTCAAAAACTTGAAACGGATGAACACTTCGGAGATTGTAAACCTATCGGTGACGGAATTAGTGAGATGAGAA
TTAATTATGCTAAAGGCTACCGACTATATTTTAAAGAAAAAGACAACAAAATCGTAATCCTTTTAATTGGTGGAGATAAA
GCAAGTCAACAAAAGGACATAGAGAAAGCGAAAAAAATCTGGAACAGAATAAAAAATGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References