Detailed information of TA system TA226263

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 2631491..2632097
• Replicon: chromosome
• Accession: NZ_CP087817
• Organism: Moraxella bovis strain SAM109237

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: LP109_RS13300
• Protein ID: WP_228157738.1
• Coordinates: 2631491..2631826 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: LP109_RS13305
• Protein ID: WP_078274722.1
• Coordinates: 2631816..2632097 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP109_RS13260 (LP109_13135)	2626838..2627128	+	291	WP_078274713.1	hypothetical protein	-
LP109_RS13265 (LP109_13140)	2627138..2627365	+	228	WP_078274714.1	hypothetical protein	-
LP109_RS13270 (LP109_13145)	2627375..2627644	+	270	WP_078274715.1	major capsid protein	-
LP109_RS13275 (LP109_13150)	2627715..2628161	+	447	WP_078274716.1	hypothetical protein	-
LP109_RS13280 (LP109_13155)	2628262..2628450	+	189	WP_078273175.1	hypothetical protein	-
LP109_RS13285 (LP109_13160)	2628437..2629891	+	1455	WP_264676478.1	virulence factor TspB C-terminal domain-related protein	-
LP109_RS13290 (LP109_13165)	2629888..2630181	+	294	WP_078274720.1	DUF2523 family protein	-
LP109_RS13295 (LP109_13170)	2630267..2631427	+	1161	WP_078274721.1	zonular occludens toxin domain-containing protein	-
LP109_RS13300 (LP109_13175)	2631491..2631826	+	336	WP_228157738.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LP109_RS13305 (LP109_13180)	2631816..2632097	+	282	WP_078274722.1	NadS family protein	Antitoxin
LP109_RS13310 (LP109_13185)	2632147..2632971	+	825	WP_078274723.1	site-specific integrase	-
LP109_RS13315 (LP109_13190)	2633087..2633299	+	213	WP_078274724.1	hypothetical protein	-
LP109_RS13320 (LP109_13195)	2633339..2634061	-	723	WP_029103568.1	nitroreductase family protein	-
LP109_RS13325 (LP109_13200)	2634206..2635531	-	1326	WP_078274725.1	hemolysin family protein	-
LP109_RS13330 (LP109_13205)	2635641..2636399	-	759	WP_078274726.1	YciK family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2592678..2682290	89612

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (43-106)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-84)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 12636.69 Da
• Isoelectric Point: 10.0972

>T226263 WP_228157738.1 NZ_CP087817:2631491-2631826 [Moraxella bovis]
MLHFAETSLFTKQIIDLMDDDEYRLLQTNLMKNPHQGDIVRGTGGVRKTRWSIDGKGKSGGSRIIYFFVDGAGIFFMLLA
YPKSKQTTLSADEKKEMLKLTTAIKEIYRAK

Nucleotide

• Length: 336 bp

>T226263 NZ_CP122326:c31385-31098 [Pantoea agglomerans pv. betae]
ATGCCCTGGCAGCTTGAGTGTGATCAGAGGGCACTGAAAGAGTGGCGCAAGCTGGGCCCGACAGTACGTGAACAGCTTAA
AAAGAAGCTGGCTGAGTGTCTTGAGTCACCCAGAATTGAGGCGAACAAACTCAGCAGGATGCCTGACTGCTATAAGATCA
AGCTAAAGTCATCCGGTTATCGACTTGCATACCAGGTTATTGATGACCGGGTGGTCGTTTTTGTGGTGGCTGTCGGGAAA
AGAGAGCGCTCAGAGGTCTGTTCTGCCGCTTCCAGGCGTCTCTCTTAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10425.98 Da
• Isoelectric Point: 10.0023

>AT226263 WP_078274722.1 NZ_CP087817:2631816-2632097 [Moraxella bovis]
VQNEFYDDLKASLTEALAIAKGEISPSRTFTYERPNIKDIRAKTGLSQTQFAQKLHISPKTLKNWEQGIRTPTGPAITLI
RLLDKNPDLISMA

Nucleotide

• Length: 282 bp

>AT226263 NZ_CP122326:c31624-31385 [Pantoea agglomerans pv. betae]
GTGGGTTCAATTAGCATCCGAATTGATGATGATCTTAAGAGACGATCCTTTGCTGCGCTCAAAAAAATGGGTGTGACGCC
CTCTGACGCGCTGCGCCTTATGCTTGCATATATTGCAGATAATGAACGTCTTCCCTTTAAGCAGACATCACTCAGTGACG
AAGATGCGGCGTTAGTAGACATAGTGGAAGAACGCCTGCGAAATCCTGAGCCTGTCAGGATCACGCTGGACAAGCTTTAA