Detailed information of TA system TA226260

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 2074384..2074990
• Replicon: chromosome
• Accession: NZ_CP087817
• Organism: Moraxella bovis strain SAM109237

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: LP109_RS10455
• Protein ID: WP_228157738.1
• Coordinates: 2074384..2074719 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: LP109_RS10460
• Protein ID: WP_078274722.1
• Coordinates: 2074709..2074990 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP109_RS10415 (LP109_10315)	2069731..2070021	+	291	WP_078274713.1	hypothetical protein	-
LP109_RS10420 (LP109_10320)	2070031..2070258	+	228	WP_078274714.1	hypothetical protein	-
LP109_RS10425 (LP109_10325)	2070268..2070537	+	270	WP_078274715.1	major capsid protein	-
LP109_RS10430 (LP109_10330)	2070608..2071054	+	447	WP_078274716.1	hypothetical protein	-
LP109_RS10435 (LP109_10335)	2071155..2071343	+	189	WP_078273175.1	hypothetical protein	-
LP109_RS10440 (LP109_10340)	2071330..2072784	+	1455	WP_264676478.1	virulence factor TspB C-terminal domain-related protein	-
LP109_RS10445 (LP109_10345)	2072781..2073074	+	294	WP_078274720.1	DUF2523 family protein	-
LP109_RS10450 (LP109_10350)	2073160..2074320	+	1161	WP_078274721.1	zonular occludens toxin domain-containing protein	-
LP109_RS10455 (LP109_10355)	2074384..2074719	+	336	WP_228157738.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LP109_RS10460 (LP109_10360)	2074709..2074990	+	282	WP_078274722.1	NadS family protein	Antitoxin
LP109_RS10465 (LP109_10365)	2075040..2075864	+	825	WP_078274723.1	site-specific integrase	-
LP109_RS10470 (LP109_10370)	2076000..2076533	-	534	WP_078273202.1	lactoylglutathione lyase	-
LP109_RS10475 (LP109_10375)	2076590..2077213	-	624	WP_078273203.1	carbonic anhydrase	-
LP109_RS10480 (LP109_10380)	2077269..2078270	-	1002	WP_078273204.1	hypothetical protein	-
LP109_RS10485 (LP109_10385)	2078443..2079543	-	1101	WP_078273205.1	3-dehydroquinate synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2070268..2107667	37399

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (43-106)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-84)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 12636.69 Da
• Isoelectric Point: 10.0972

>T226260 WP_228157738.1 NZ_CP087817:2074384-2074719 [Moraxella bovis]
MLHFAETSLFTKQIIDLMDDDEYRLLQTNLMKNPHQGDIVRGTGGVRKTRWSIDGKGKSGGSRIIYFFVDGAGIFFMLLA
YPKSKQTTLSADEKKEMLKLTTAIKEIYRAK

Nucleotide

• Length: 336 bp

>T226260 NZ_CP122322:132978-133265 [Pantoea agglomerans pv. gypsophilae]
ATGACCTGGCAACTGGAGTTCGATCAGAGGGCACTGAAAGAGTGGCGCAAGCTGGGCCCGACAGTACGTGAACAGCTTAA
AAAGAAGCTGGCTGAGTGTCTTGAGTCACCCAGAATTGAGGCGAACAAACTCAGCGGGATGCCTGACTGCTATAAGATCA
AGCTAAAGTCATCCGGTTATCGACTTGTATACCAGGTTATTGATGACCGGGTGGTGGTTTTTGTGGTGGCTGTCGTGAAA
AGAGAGCGCTCAGAGGTTTATTCTGCCGCTTCCAGGCGTCTCTCTTAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10425.98 Da
• Isoelectric Point: 10.0023

>AT226260 WP_078274722.1 NZ_CP087817:2074709-2074990 [Moraxella bovis]
VQNEFYDDLKASLTEALAIAKGEISPSRTFTYERPNIKDIRAKTGLSQTQFAQKLHISPKTLKNWEQGIRTPTGPAITLI
RLLDKNPDLISMA

Nucleotide

• Length: 282 bp

>AT226260 NZ_CP122322:132739-132978 [Pantoea agglomerans pv. gypsophilae]
ATGGGCACAATTAACATTCGAATCGATGATGACCTGAAGACACGATCCTATGCTGCGCTCGAAAAAATGGGTGTGACTCC
TTCTGATGCGCTGCGCCTGATGCTTGAATATATTGCAGATAATGAACGTCTTCCCTTTAAGCAAACGTTACTCAGTGACG
AAGATGCGGCGTTAGTAGACATAGTTAAAGAACGCCTGCGAAACCCTGAGCCTGTCCGGGTCACACTGGATGACCTTTAA