Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 1469384..1469989 | Replicon | chromosome |
| Accession | NC_010296 | ||
| Organism | Microcystis aeruginosa NIES-843 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | I4IIC1 |
| Locus tag | MAE_RS07195 | Protein ID | WP_008206034.1 |
| Coordinates | 1469708..1469989 (-) | Length | 94 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | MAE_RS07190 | Protein ID | WP_002737909.1 |
| Coordinates | 1469384..1469698 (-) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MAE_RS07175 | 1464670..1468488 | - | 3819 | WP_012264977.1 | CHAT domain-containing protein | - |
| MAE_RS07180 | 1468614..1468835 | - | 222 | WP_002800940.1 | type II toxin-antitoxin system HicA family toxin | - |
| MAE_RS07185 | 1468825..1469031 | - | 207 | WP_002798743.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| MAE_RS07190 | 1469384..1469698 | - | 315 | WP_002737909.1 | HigA family addiction module antidote protein | Antitoxin |
| MAE_RS07195 | 1469708..1469989 | - | 282 | WP_008206034.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| MAE_RS34000 | 1470289..1470447 | - | 159 | WP_012264980.1 | hypothetical protein | - |
| MAE_RS07200 | 1470566..1470778 | - | 213 | WP_002759169.1 | type II toxin-antitoxin system HicA family toxin | - |
| MAE_RS07205 | 1470771..1470977 | - | 207 | WP_012264985.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| MAE_RS07210 | 1471035..1471319 | - | 285 | Protein_1469 | type II toxin-antitoxin system HicB family antitoxin | - |
| MAE_RS07215 | 1471501..1471761 | + | 261 | WP_041803907.1 | hypothetical protein | - |
| MAE_RS07220 | 1471748..1472170 | + | 423 | WP_012264982.1 | PIN domain-containing protein | - |
| MAE_RS07225 | 1472242..1472589 | - | 348 | WP_002751511.1 | hypothetical protein | - |
| MAE_RS28750 | 1472570..1472866 | - | 297 | WP_004163330.1 | hypothetical protein | - |
| MAE_RS34005 | 1473013..1473168 | - | 156 | WP_004163331.1 | hypothetical protein | - |
| MAE_RS07235 | 1473287..1473499 | - | 213 | WP_012264984.1 | type II toxin-antitoxin system HicA family toxin | - |
| MAE_RS07240 | 1473492..1473698 | - | 207 | WP_012264985.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| MAE_RS34310 | 1473693..1473893 | - | 201 | Protein_1477 | type II toxin-antitoxin system HicB family antitoxin | - |
| MAE_RS07250 | 1474412..1474759 | - | 348 | Protein_1478 | IS4 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 11099.70 Da Isoelectric Point: 9.0320
>T22626 WP_008206034.1 NC_010296:c1469989-1469708 [Microcystis aeruginosa NIES-843]
VIQNFKDKEAQKVFERKHSRKLPLDIQQVALRKLRMLNRAETLQDLRVPPANRLERLVGDREGQYSIRVNDQWQICFVWQ
NGDALDVEIVDYH
VIQNFKDKEAQKVFERKHSRKLPLDIQQVALRKLRMLNRAETLQDLRVPPANRLERLVGDREGQYSIRVNDQWQICFVWQ
NGDALDVEIVDYH
Download Length: 282 bp
>T22626 NC_010296:c1469989-1469708 [Microcystis aeruginosa NIES-843]
GTGATCCAAAACTTTAAAGATAAAGAAGCTCAAAAAGTTTTTGAACGTAAACATTCGCGTAAATTGCCATTAGATATCCA
ACAAGTGGCATTGCGAAAATTGCGGATGCTTAATCGTGCGGAAACCCTGCAAGATCTTCGTGTCCCACCAGCAAATCGAT
TGGAACGTCTGGTTGGTGACAGGGAAGGTCAATATAGCATTCGGGTTAACGATCAATGGCAAATTTGCTTTGTCTGGCAA
AACGGTGATGCTCTAGACGTAGAAATCGTTGATTATCATTGA
GTGATCCAAAACTTTAAAGATAAAGAAGCTCAAAAAGTTTTTGAACGTAAACATTCGCGTAAATTGCCATTAGATATCCA
ACAAGTGGCATTGCGAAAATTGCGGATGCTTAATCGTGCGGAAACCCTGCAAGATCTTCGTGTCCCACCAGCAAATCGAT
TGGAACGTCTGGTTGGTGACAGGGAAGGTCAATATAGCATTCGGGTTAACGATCAATGGCAAATTTGCTTTGTCTGGCAA
AACGGTGATGCTCTAGACGTAGAAATCGTTGATTATCATTGA
Antitoxin
Download Length: 105 a.a. Molecular weight: 11846.78 Da Isoelectric Point: 4.1648
>AT22626 WP_002737909.1 NC_010296:c1469698-1469384 [Microcystis aeruginosa NIES-843]
MNEDKLMPIHPGEVLLEEFIKPMNLSQNQIALALGVPEQCINEIVHGKRCITADIALRLARYFDMSPRFWLGLQMDYDLD
VVEDEIGDQLDKEVAVMTVICAEK
MNEDKLMPIHPGEVLLEEFIKPMNLSQNQIALALGVPEQCINEIVHGKRCITADIALRLARYFDMSPRFWLGLQMDYDLD
VVEDEIGDQLDKEVAVMTVICAEK
Download Length: 315 bp
>AT22626 NC_010296:c1469698-1469384 [Microcystis aeruginosa NIES-843]
ATGAATGAAGATAAACTAATGCCAATTCATCCCGGTGAGGTTCTTTTAGAGGAATTTATCAAGCCAATGAACCTTAGTCA
GAATCAAATAGCTCTGGCTCTTGGAGTTCCTGAACAATGTATTAACGAAATCGTTCACGGAAAGCGGTGTATCACGGCGG
ATATAGCTCTTCGGTTAGCTCGTTATTTTGATATGTCACCGCGATTTTGGCTGGGATTACAAATGGATTACGATCTGGAC
GTTGTTGAAGATGAAATAGGAGATCAATTGGACAAAGAAGTTGCTGTAATGACAGTTATTTGTGCAGAAAAGTAA
ATGAATGAAGATAAACTAATGCCAATTCATCCCGGTGAGGTTCTTTTAGAGGAATTTATCAAGCCAATGAACCTTAGTCA
GAATCAAATAGCTCTGGCTCTTGGAGTTCCTGAACAATGTATTAACGAAATCGTTCACGGAAAGCGGTGTATCACGGCGG
ATATAGCTCTTCGGTTAGCTCGTTATTTTGATATGTCACCGCGATTTTGGCTGGGATTACAAATGGATTACGATCTGGAC
GTTGTTGAAGATGAAATAGGAGATCAATTGGACAAAGAAGTTGCTGTAATGACAGTTATTTGTGCAGAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|