Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1756832..1757430 Replicon chromosome
Accession NZ_CP087817
Organism Moraxella bovis strain SAM109237

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LP109_RS08705 Protein ID WP_078275306.1
Coordinates 1756832..1757110 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag LP109_RS08710 Protein ID WP_078275307.1
Coordinates 1757125..1757430 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP109_RS08680 (LP109_08590) 1753059..1753601 - 543 WP_244893697.1 D-Ala-D-Ala carboxypeptidase family metallohydrolase -
LP109_RS08685 (LP109_08595) 1753625..1753942 - 318 WP_078275302.1 phage holin family protein -
LP109_RS08690 (LP109_08600) 1754051..1754935 - 885 WP_078275303.1 hypothetical protein -
LP109_RS08695 (LP109_08605) 1755088..1756137 - 1050 WP_078275304.1 host specificity protein J -
LP109_RS08700 (LP109_08610) 1756162..1756746 - 585 WP_078275305.1 tail assembly protein -
LP109_RS08705 (LP109_08615) 1756832..1757110 + 279 WP_078275306.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LP109_RS08710 (LP109_08620) 1757125..1757430 + 306 WP_078275307.1 HigA family addiction module antitoxin Antitoxin
LP109_RS08715 (LP109_08625) 1757402..1758178 - 777 WP_078275308.1 C40 family peptidase -
LP109_RS08720 (LP109_08630) 1758246..1758434 - 189 WP_078275309.1 hypothetical protein -
LP109_RS08725 (LP109_08635) 1758431..1758973 - 543 WP_078275310.1 antA/AntB antirepressor family protein -
LP109_RS08730 (LP109_08640) 1759146..1759376 + 231 WP_078275311.1 Arc family DNA-binding protein -
LP109_RS08735 (LP109_08645) 1759418..1760101 - 684 WP_078275312.1 phage minor tail protein L -
LP109_RS08740 (LP109_08650) 1760098..1760487 - 390 WP_078275313.1 hypothetical protein -
LP109_RS08745 (LP109_08655) 1760523..1760855 - 333 WP_078275314.1 phage tail protein -
LP109_RS08750 (LP109_08660) 1760852..1761013 - 162 WP_158079719.1 hypothetical protein -
LP109_RS08755 (LP109_08665) 1761085..1762278 - 1194 WP_244893698.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1744343..1778796 34453


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-95)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10491.92 Da        Isoelectric Point: 5.0474

>T226257 WP_078275306.1 NZ_CP087817:1756832-1757110 [Moraxella bovis]
MIQSFKCKDAQSLFETGSSRVFANFLSVATRKLTMLDNAVALADLRIPPANRLEKLTGDREGQYSIRINDQFRICFVWGD
DGVYDVEIVDYH

Download         Length: 279 bp

>T226257 NZ_CP122321:c319625-319314 [Pantoea agglomerans pv. gypsophilae]
ATGCATATCATCTCAAGAGGGCCGTTCAGGGAAGCGGCAATAATTTATCCAAATCATGCCTCCGCACTGGATGCGGCTTA
TCTGGTCCTAAGGGACGAAAACTTTGCCACGCCAGATGCGCTGAAAATTCGCTTTCAGAGCCTTGACCGCATGAAGTACC
GGGAAAAGTGGTGGGTAATCGATGTGGGCGGAAACAGCCTGAGAATCATGTTTTATGCTGACTTTGATCGCGGCAAAATT
TTTATCAAACACATCGTGACGCATGCGGAATATGACAAGCTGGTGAAGAAGTACCGGGAGAGTAAAGAATGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11173.81 Da        Isoelectric Point: 7.3174

>AT226257 WP_078275307.1 NZ_CP087817:1757125-1757430 [Moraxella bovis]
MFKNGMRPVHAGEVLREEYLIPMGMSATALANALGVTPARINDIVRQRRGVTADTALRLARYFGGTAQFWLNLQTTYELR
LAETTLGDSLDFISPHEVAHA

Download         Length: 306 bp

>AT226257 NZ_CP122321:c319317-318904 [Pantoea agglomerans pv. gypsophilae]
ATGATTACCGAAGCAATCCAGGCGACCAATGACCTGGTCAGAATTGTTCCCTTTCTGGGAGGCAGTACCGATAAAAGGGA
CTACGAGCAGGCGCTGGAACTGGTTGAATATCTGGTTGAGCACCAGCCGGACAGCCCGTTAGTAGAGATACTGTCTGATA
AAGTCGCCCGATACGAAAACAGCGCCCCTGAGTTCGCTGCGTTTAACGCGCGTACTGATGCTATTCCGCGCGGAGTAGCA
CTTTTGCGAGTCATCATGGATCAGCACGGCCTGACTCAATCCTCTTTTGCGGATGAAATAGGGCAGCACTCTTATGTCAG
TCGTATCCTGCGTGGTGATCGTCCTTTGACGGATAAACATAAAGCCCGACTGGCAGCGCGTTTTAACCTGCCGTTTGAAG
CATTCGCTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References