Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2712705..2713311 Replicon chromosome
Accession NZ_CP087814
Organism Moraxella bovis strain SAM109238

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LP088_RS13855 Protein ID WP_228157738.1
Coordinates 2712705..2713040 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LP088_RS13860 Protein ID WP_078274722.1
Coordinates 2713030..2713311 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP088_RS13810 2707766..2707900 + 135 WP_264676041.1 hypothetical protein -
LP088_RS13815 (LP088_13685) 2707952..2708107 + 156 WP_158079680.1 hypothetical protein -
LP088_RS13820 (LP088_13690) 2708102..2708377 - 276 WP_078274708.1 hypothetical protein -
LP088_RS13825 (LP088_13695) 2708664..2708909 - 246 WP_078274709.1 hypothetical protein -
LP088_RS13830 (LP088_13700) 2709032..2709361 - 330 WP_264676042.1 hypothetical protein -
LP088_RS13835 (LP088_13705) 2709480..2709737 + 258 WP_112741693.1 hypothetical protein -
LP088_RS13840 (LP088_13710) 2710230..2711105 + 876 WP_162860331.1 virulence factor TspB C-terminal domain-related protein -
LP088_RS13845 (LP088_13715) 2711102..2711395 + 294 WP_078274720.1 DUF2523 family protein -
LP088_RS13850 (LP088_13720) 2711481..2712641 + 1161 WP_078274721.1 zonular occludens toxin domain-containing protein -
LP088_RS13855 (LP088_13725) 2712705..2713040 + 336 WP_228157738.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LP088_RS13860 (LP088_13730) 2713030..2713311 + 282 WP_078274722.1 NadS family protein Antitoxin
LP088_RS13865 (LP088_13735) 2713361..2714185 + 825 WP_078274723.1 site-specific integrase -
LP088_RS13870 (LP088_13740) 2714301..2714513 + 213 WP_078274724.1 hypothetical protein -
LP088_RS13875 (LP088_13745) 2714553..2715275 - 723 WP_029103568.1 nitroreductase family protein -
LP088_RS13880 (LP088_13750) 2715420..2716745 - 1326 WP_112741690.1 hemolysin family protein -
LP088_RS13885 (LP088_13755) 2716855..2717613 - 759 WP_078274726.1 YciK family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-84)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12636.69 Da        Isoelectric Point: 10.0972

>T226253 WP_228157738.1 NZ_CP087814:2712705-2713040 [Moraxella bovis]
MLHFAETSLFTKQIIDLMDDDEYRLLQTNLMKNPHQGDIVRGTGGVRKTRWSIDGKGKSGGSRIIYFFVDGAGIFFMLLA
YPKSKQTTLSADEKKEMLKLTTAIKEIYRAK

Download         Length: 336 bp

>T226253 NZ_CP122320:c3036814-3035501 [Pantoea agglomerans pv. gypsophilae]
ATGCAAAGGCTGATTGCGTGGATGAACGGCGAGCGGGTAGGCGTACTCACCCGGCAGCGAAACGGCGCTCATGAGTTTCA
GTATGATACCGGCTGGCTGAGTAATCCGCTCTCCAGGCCGCTGTCACTTTCGATGCCGTTGCAGGTAAAGGCTCTCACCT
CACACGCCGTGATTAACTTCTTCGATAACCTGCTGCCGGATAGCCCATTGATTCGCGACAGAATCGTGGCGCGTTACCAG
ATTAAATCCCGTCAGCCCTTTGATCTGTTGCAGGAAGTGGGACGTGACAGCGTCGGGGCGACTATGCTGCTGCCGCCCGA
TATGCCACTGCCCGCACTGCAGGCCCGCTATGAAGTGCTGGATGAAACCCGGCTCGAAAGCGTGCTGTCGGCCTATCAGT
CAGATATCCCGCTGGGGATGCTGCGTGAAGAGACCGATTTCCGTATCTCGGTCGCGGGGGTGCAGGAGAAAACCGCACTG
CTGCTGACCGATGAAGGCTGGAGCATTCCTGCCGGTGCCACGCCCACCTCGCACATCATTAAGCTGCCGATCGGAGAGAT
TAAACAGCCGGCCGCGACGCTGGATATGCGTGAAAGTGTGGAGAATGAGTATCTCTGTCTGGCGCTGGCCCGTGCACTCG
GTATCGACGTGCCGCAGGCAACGATTATTCGTGCCGGACAGATGCGCGCCCTGGCGGTAGAACGTTTCGACCGCCGCTGG
TCACGCGATAAAACCCGGTTGATTCGCCTGCCGCAGGAGGATTTCTGTCAGGCGCTGGGACTGCCTTCTTCAACCAAATA
TGAGTCGGATGGCGGGCCGGGTATTGCGGAGATCATGCAGATACTGATGGGATCGAGCAACGCCATCGAAGATCGCTATC
GCTTTATGATGTTCCAGGTGTTTCAGTGGCTGATTGGCGCAACCGACGGTCACGCCAAGAACTTCTCACTGTTTATTGAG
CGCGGCGGCAGTTATCGACTGACTCCCTTTTATGATGTGATCTCCGCTTATCCGGTACTGGGCGGCACCGGTCTGAACAA
GCGAGCGCTGAAACTGGCGATGGGGCTGCGTGCCACTAAGGGGAAGAAGACAGAGATCGACAAAATCTTCCCGCGCCATT
TTATCGCCACGGCAAAAAGCGTCAGTTTTGATCGTGACAGTTTGCAGCAGATCTTCGACTTCTTTATTAAGGCCTTTCCC
CAGGCAGTGGTCTCGGTGCGCGATGCTTTGCCGCCCGATTTCCCGCAGCACATCGCCGACGCCATCTTCAGTCATTCACT
GATTATGCTGGAGCGGCTGCGGCACAAAGAGTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10425.98 Da        Isoelectric Point: 10.0023

>AT226253 WP_078274722.1 NZ_CP087814:2713030-2713311 [Moraxella bovis]
VQNEFYDDLKASLTEALAIAKGEISPSRTFTYERPNIKDIRAKTGLSQTQFAQKLHISPKTLKNWEQGIRTPTGPAITLI
RLLDKNPDLISMA

Download         Length: 282 bp

>AT226253 NZ_CP122320:c3037062-3036814 [Pantoea agglomerans pv. gypsophilae]
ATGATATACAGCCCGCTACAGCTGGCAAACCGGCTAAAGCTCATTCGTCAGCGTAATGGCTGGACCCAAAGTGAGCTGGC
GAAAAAGGTCGGCCTGAAACAGGCCACCATCTCTCACTTTGAAAATGCCCCTGACAGTACCTCGCTGGCAACGCTGTTTA
AGCTGTTACAGTCGCTGGAGCTGAGTCTGGAAGTTCAGGAGAAAGAGGAGGCCGGTGCGCCTCAGCTGCATGATGAGGAT
GAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References