Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 916642..917240 Replicon chromosome
Accession NZ_CP087814
Organism Moraxella bovis strain SAM109238

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LP088_RS04910 Protein ID WP_078275306.1
Coordinates 916962..917240 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag LP088_RS04905 Protein ID WP_078275307.1
Coordinates 916642..916947 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP088_RS04870 (LP088_04850) 912295..912495 - 201 WP_062501372.1 hypothetical protein -
LP088_RS04875 (LP088_04855) 912874..913920 + 1047 WP_264690420.1 tape measure protein -
LP088_RS04880 (LP088_04860) 913917..914600 + 684 WP_264676213.1 phage minor tail protein L -
LP088_RS04885 (LP088_04865) 914642..914872 - 231 WP_078275311.1 Arc family DNA-binding protein -
LP088_RS04890 (LP088_04870) 915045..915641 + 597 WP_264676214.1 antA/AntB antirepressor family protein -
LP088_RS04895 (LP088_04875) 915638..915826 + 189 WP_078275309.1 hypothetical protein -
LP088_RS04900 (LP088_04880) 915894..916670 + 777 WP_078275308.1 C40 family peptidase -
LP088_RS04905 (LP088_04885) 916642..916947 - 306 WP_078275307.1 HigA family addiction module antitoxin Antitoxin
LP088_RS04910 (LP088_04890) 916962..917240 - 279 WP_078275306.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LP088_RS04915 (LP088_04895) 917326..917910 + 585 WP_264676215.1 tail assembly protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 888054..932654 44600


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-95)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10491.92 Da        Isoelectric Point: 5.0474

>T226246 WP_078275306.1 NZ_CP087814:c917240-916962 [Moraxella bovis]
MIQSFKCKDAQSLFETGSSRVFANFLSVATRKLTMLDNAVALADLRIPPANRLEKLTGDREGQYSIRINDQFRICFVWGD
DGVYDVEIVDYH

Download         Length: 279 bp

>T226246 NZ_CP122319:c4524540-4524286 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11173.81 Da        Isoelectric Point: 7.3174

>AT226246 WP_078275307.1 NZ_CP087814:c916947-916642 [Moraxella bovis]
MFKNGMRPVHAGEVLREEYLIPMGMSATALANALGVTPARINDIVRQRRGVTADTALRLARYFGGTAQFWLNLQTTYELR
LAETTLGDSLDFISPHEVAHA

Download         Length: 306 bp

>AT226246 NZ_CP122319:c4524788-4524537 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References