Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1794509..1795107 Replicon chromosome
Accession NZ_CP087811
Organism Moraxella bovis strain SAM57928

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LP106_RS08960 Protein ID WP_078275306.1
Coordinates 1794509..1794787 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag LP106_RS08965 Protein ID WP_078275307.1
Coordinates 1794802..1795107 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP106_RS08940 (LP106_08855) 1789850..1790392 - 543 WP_244893697.1 D-Ala-D-Ala carboxypeptidase family metallohydrolase -
LP106_RS08945 (LP106_08860) 1790416..1790733 - 318 WP_078275302.1 phage holin family protein -
LP106_RS08950 (LP106_08865) 1790842..1793814 - 2973 WP_264722096.1 phage tail protein -
LP106_RS08955 (LP106_08870) 1793839..1794423 - 585 WP_264676215.1 tail assembly protein -
LP106_RS08960 (LP106_08875) 1794509..1794787 + 279 WP_078275306.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LP106_RS08965 (LP106_08880) 1794802..1795107 + 306 WP_078275307.1 HigA family addiction module antitoxin Antitoxin
LP106_RS08970 (LP106_08885) 1795079..1795855 - 777 WP_078275308.1 C40 family peptidase -
LP106_RS08975 (LP106_08890) 1795923..1796111 - 189 WP_078275309.1 hypothetical protein -
LP106_RS08980 (LP106_08895) 1796108..1796704 - 597 WP_264676214.1 antA/AntB antirepressor family protein -
LP106_RS08985 (LP106_08900) 1796877..1797107 + 231 WP_078275311.1 Arc family DNA-binding protein -
LP106_RS08990 (LP106_08905) 1797149..1797832 - 684 WP_264676213.1 phage minor tail protein L -
LP106_RS08995 (LP106_08910) 1797829..1798218 - 390 WP_078275313.1 hypothetical protein -
LP106_RS09000 (LP106_08915) 1798254..1798586 - 333 WP_078275314.1 phage tail protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1788543..1833938 45395


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-95)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10491.92 Da        Isoelectric Point: 5.0474

>T226239 WP_078275306.1 NZ_CP087811:1794509-1794787 [Moraxella bovis]
MIQSFKCKDAQSLFETGSSRVFANFLSVATRKLTMLDNAVALADLRIPPANRLEKLTGDREGQYSIRINDQFRICFVWGD
DGVYDVEIVDYH

Download         Length: 279 bp

>T226239 NZ_CP122319:c3707395-3707288 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11173.81 Da        Isoelectric Point: 7.3174

>AT226239 WP_078275307.1 NZ_CP087811:1794802-1795107 [Moraxella bovis]
MFKNGMRPVHAGEVLREEYLIPMGMSATALANALGVTPARINDIVRQRRGVTADTALRLARYFGGTAQFWLNLQTTYELR
LAETTLGDSLDFISPHEVAHA

Download         Length: 306 bp

>AT226239 NZ_CP122319:3707442-3707508 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References