Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 100037..100643 Replicon chromosome
Accession NZ_CP087811
Organism Moraxella bovis strain SAM57928

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LP106_RS00490 Protein ID WP_228157738.1
Coordinates 100308..100643 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LP106_RS00485 Protein ID WP_078274722.1
Coordinates 100037..100318 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP106_RS00460 (LP106_00465) 95735..96493 + 759 WP_078274726.1 YciK family oxidoreductase -
LP106_RS00465 (LP106_00470) 96603..97928 + 1326 WP_112741690.1 hemolysin family protein -
LP106_RS00470 (LP106_00475) 98073..98795 + 723 WP_029103568.1 nitroreductase family protein -
LP106_RS00475 (LP106_00480) 98835..99047 - 213 WP_078274724.1 hypothetical protein -
LP106_RS00480 (LP106_00485) 99163..99987 - 825 WP_078274723.1 site-specific integrase -
LP106_RS00485 (LP106_00490) 100037..100318 - 282 WP_078274722.1 NadS family protein Antitoxin
LP106_RS00490 (LP106_00495) 100308..100643 - 336 WP_228157738.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LP106_RS00495 (LP106_00500) 100707..101867 - 1161 WP_078274721.1 zonular occludens toxin domain-containing protein -
LP106_RS00500 (LP106_00505) 101953..102246 - 294 WP_078274720.1 DUF2523 family protein -
LP106_RS00505 (LP106_00510) 102243..103118 - 876 WP_162860331.1 virulence factor TspB C-terminal domain-related protein -
LP106_RS00510 (LP106_00515) 103611..103868 - 258 WP_112741693.1 hypothetical protein -
LP106_RS00515 (LP106_00520) 103987..104316 + 330 WP_264676042.1 hypothetical protein -
LP106_RS00520 (LP106_00525) 104439..104684 + 246 WP_078274709.1 hypothetical protein -
LP106_RS00525 (LP106_00530) 104971..105246 + 276 WP_078274708.1 hypothetical protein -
LP106_RS00530 (LP106_00535) 105241..105396 - 156 WP_158079680.1 hypothetical protein -
LP106_RS00535 105448..105582 - 135 WP_264676041.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-84)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12636.69 Da        Isoelectric Point: 10.0972

>T226232 WP_228157738.1 NZ_CP087811:c100643-100308 [Moraxella bovis]
MLHFAETSLFTKQIIDLMDDDEYRLLQTNLMKNPHQGDIVRGTGGVRKTRWSIDGKGKSGGSRIIYFFVDGAGIFFMLLA
YPKSKQTTLSADEKKEMLKLTTAIKEIYRAK

Download         Length: 336 bp

>T226232 NZ_CP122319:c2379235-2378894 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10425.98 Da        Isoelectric Point: 10.0023

>AT226232 WP_078274722.1 NZ_CP087811:c100318-100037 [Moraxella bovis]
VQNEFYDDLKASLTEALAIAKGEISPSRTFTYERPNIKDIRAKTGLSQTQFAQKLHISPKTLKNWEQGIRTPTGPAITLI
RLLDKNPDLISMA

Download         Length: 282 bp

>AT226232 NZ_CP122319:2379230-2379306 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References