Detailed information of TA system TA226229

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 1853139..1853745
• Replicon: chromosome
• Accession: NZ_CP087806
• Organism: Moraxella bovis strain SAM57939

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: LP117_RS09405
• Protein ID: WP_228157738.1
• Coordinates: 1853410..1853745 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: LP117_RS09400
• Protein ID: WP_078274722.1
• Coordinates: 1853139..1853420 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP117_RS09375 (LP117_09305)	1848837..1849595	+	759	WP_078274726.1	YciK family oxidoreductase	-
LP117_RS09380 (LP117_09310)	1849705..1851030	+	1326	WP_112741690.1	hemolysin family protein	-
LP117_RS09385 (LP117_09315)	1851175..1851897	+	723	WP_029103568.1	nitroreductase family protein	-
LP117_RS09390 (LP117_09320)	1851937..1852149	-	213	WP_078274724.1	hypothetical protein	-
LP117_RS09395 (LP117_09325)	1852265..1853089	-	825	WP_078274723.1	site-specific integrase	-
LP117_RS09400 (LP117_09330)	1853139..1853420	-	282	WP_078274722.1	NadS family protein	Antitoxin
LP117_RS09405 (LP117_09335)	1853410..1853745	-	336	WP_228157738.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LP117_RS09410 (LP117_09340)	1853809..1854969	-	1161	WP_078274721.1	zonular occludens toxin domain-containing protein	-
LP117_RS09415 (LP117_09345)	1855055..1855348	-	294	WP_078274720.1	DUF2523 family protein	-
LP117_RS09420 (LP117_09350)	1855345..1856220	-	876	WP_162860331.1	virulence factor TspB C-terminal domain-related protein	-
LP117_RS09425 (LP117_09355)	1856713..1856970	-	258	WP_112741693.1	hypothetical protein	-
LP117_RS09430 (LP117_09360)	1857041..1857418	+	378	WP_264684286.1	hypothetical protein	-
LP117_RS09435 (LP117_09365)	1857541..1857786	+	246	WP_078274709.1	hypothetical protein	-
LP117_RS09440 (LP117_09370)	1858073..1858348	+	276	WP_078274708.1	hypothetical protein	-
LP117_RS09445 (LP117_09375)	1858343..1858498	-	156	WP_158079680.1	hypothetical protein	-
LP117_RS09450	1858550..1858684	-	135	WP_264676041.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (43-106)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-84)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 12636.69 Da
• Isoelectric Point: 10.0972

>T226229 WP_228157738.1 NZ_CP087806:c1853745-1853410 [Moraxella bovis]
MLHFAETSLFTKQIIDLMDDDEYRLLQTNLMKNPHQGDIVRGTGGVRKTRWSIDGKGKSGGSRIIYFFVDGAGIFFMLLA
YPKSKQTTLSADEKKEMLKLTTAIKEIYRAK

Nucleotide

• Length: 336 bp

>T226229 NZ_CP122319:2152303-2152476 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10425.98 Da
• Isoelectric Point: 10.0023

>AT226229 WP_078274722.1 NZ_CP087806:c1853420-1853139 [Moraxella bovis]
VQNEFYDDLKASLTEALAIAKGEISPSRTFTYERPNIKDIRAKTGLSQTQFAQKLHISPKTLKNWEQGIRTPTGPAITLI
RLLDKNPDLISMA

Nucleotide

• Length: 282 bp

>AT226229 NZ_CP122319:2151979-2152275 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG