Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 480702..481300 Replicon chromosome
Accession NZ_CP087806
Organism Moraxella bovis strain SAM57939

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LP117_RS02620 Protein ID WP_078275306.1
Coordinates 481022..481300 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag LP117_RS02615 Protein ID WP_078275307.1
Coordinates 480702..481007 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP117_RS02575 (LP117_02565) 477119..477280 + 162 WP_158079719.1 hypothetical protein -
LP117_RS02580 (LP117_02570) 477277..477609 + 333 WP_078275314.1 phage tail protein -
LP117_RS02585 (LP117_02575) 477645..478034 + 390 WP_078275313.1 hypothetical protein -
LP117_RS02590 (LP117_02580) 478031..478714 + 684 WP_078275312.1 phage minor tail protein L -
LP117_RS02595 (LP117_02585) 478756..478986 - 231 WP_078275311.1 Arc family DNA-binding protein -
LP117_RS02600 (LP117_02590) 479159..479701 + 543 WP_078275310.1 antA/AntB antirepressor family protein -
LP117_RS02605 (LP117_02595) 479698..479886 + 189 WP_078275309.1 hypothetical protein -
LP117_RS02610 (LP117_02600) 479954..480730 + 777 WP_112742102.1 C40 family peptidase -
LP117_RS02615 (LP117_02605) 480702..481007 - 306 WP_078275307.1 HigA family addiction module antitoxin Antitoxin
LP117_RS02620 (LP117_02610) 481022..481300 - 279 WP_078275306.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LP117_RS02625 (LP117_02615) 481386..481970 + 585 WP_264676215.1 tail assembly protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 442681..490303 47622


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-95)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10491.92 Da        Isoelectric Point: 5.0474

>T226223 WP_078275306.1 NZ_CP087806:c481300-481022 [Moraxella bovis]
MIQSFKCKDAQSLFETGSSRVFANFLSVATRKLTMLDNAVALADLRIPPANRLEKLTGDREGQYSIRINDQFRICFVWGD
DGVYDVEIVDYH

Download         Length: 279 bp

>T226223 NZ_CP122319:c714027-713692 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11173.81 Da        Isoelectric Point: 7.3174

>AT226223 WP_078275307.1 NZ_CP087806:c481007-480702 [Moraxella bovis]
MFKNGMRPVHAGEVLREEYLIPMGMSATALANALGVTPARINDIVRQRRGVTADTALRLARYFGGTAQFWLNLQTTYELR
LAETTLGDSLDFISPHEVAHA

Download         Length: 306 bp

>AT226223 NZ_CP122319:c714275-714027 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References