Detailed information of TA system TA226208

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 1836862..1837460
• Replicon: chromosome
• Accession: NZ_CP087803
• Organism: Moraxella bovis strain SAM57947

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: LP097_RS09370
• Protein ID: WP_078275306.1
• Coordinates: 1836862..1837140 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: graA
• Uniprot ID: -
• Locus tag: LP097_RS09375
• Protein ID: WP_078275307.1
• Coordinates: 1837155..1837460 (+)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP097_RS09365 (LP097_09255)	1836192..1836776	-	585	WP_264676215.1	tail assembly protein	-
LP097_RS09370 (LP097_09260)	1836862..1837140	+	279	WP_078275306.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LP097_RS09375 (LP097_09265)	1837155..1837460	+	306	WP_078275307.1	HigA family addiction module antitoxin	Antitoxin
LP097_RS09380 (LP097_09270)	1837432..1838208	-	777	WP_112742102.1	C40 family peptidase	-
LP097_RS09385 (LP097_09275)	1838276..1838464	-	189	WP_078275309.1	hypothetical protein	-
LP097_RS09390 (LP097_09280)	1838461..1839003	-	543	WP_078275310.1	antA/AntB antirepressor family protein	-
LP097_RS09395 (LP097_09285)	1839176..1839406	+	231	WP_078275311.1	Arc family DNA-binding protein	-
LP097_RS09400 (LP097_09290)	1839448..1840131	-	684	WP_078275312.1	phage minor tail protein L	-
LP097_RS09405 (LP097_09295)	1840128..1840517	-	390	WP_078275313.1	hypothetical protein	-
LP097_RS09410 (LP097_09300)	1840553..1840885	-	333	WP_078275314.1	phage tail protein	-
LP097_RS09415 (LP097_09305)	1840882..1841043	-	162	WP_158079719.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1827859..1875477	47618

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-92)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (1-95)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10491.92 Da
• Isoelectric Point: 5.0474

>T226208 WP_078275306.1 NZ_CP087803:1836862-1837140 [Moraxella bovis]
MIQSFKCKDAQSLFETGSSRVFANFLSVATRKLTMLDNAVALADLRIPPANRLEKLTGDREGQYSIRINDQFRICFVWGD
DGVYDVEIVDYH

Nucleotide

• Length: 279 bp

>T226208 NZ_CP122318:1644241-1644348 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 11173.81 Da
• Isoelectric Point: 7.3174

>AT226208 WP_078275307.1 NZ_CP087803:1837155-1837460 [Moraxella bovis]
MFKNGMRPVHAGEVLREEYLIPMGMSATALANALGVTPARINDIVRQRRGVTADTALRLARYFGGTAQFWLNLQTTYELR
LAETTLGDSLDFISPHEVAHA

Nucleotide

• Length: 306 bp

>AT226208 NZ_CP122318:c1644191-1644128 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCT