Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 136197..136803 Replicon chromosome
Accession NZ_CP087803
Organism Moraxella bovis strain SAM57947

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LP097_RS00750 Protein ID WP_228157738.1
Coordinates 136468..136803 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LP097_RS00745 Protein ID WP_078274722.1
Coordinates 136197..136478 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP097_RS00720 (LP097_00720) 131895..132653 + 759 WP_078274726.1 YciK family oxidoreductase -
LP097_RS00725 (LP097_00725) 132763..134088 + 1326 WP_112741690.1 hemolysin family protein -
LP097_RS00730 (LP097_00730) 134233..134955 + 723 WP_029103568.1 nitroreductase family protein -
LP097_RS00735 (LP097_00735) 134995..135207 - 213 WP_078274724.1 hypothetical protein -
LP097_RS00740 (LP097_00740) 135323..136147 - 825 WP_078274723.1 site-specific integrase -
LP097_RS00745 (LP097_00745) 136197..136478 - 282 WP_078274722.1 NadS family protein Antitoxin
LP097_RS00750 (LP097_00750) 136468..136803 - 336 WP_228157738.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LP097_RS00755 (LP097_00755) 136867..138027 - 1161 WP_078274721.1 zonular occludens toxin domain-containing protein -
LP097_RS00760 (LP097_00760) 138113..138406 - 294 WP_078274720.1 DUF2523 family protein -
LP097_RS00765 (LP097_00765) 138403..139278 - 876 WP_162860331.1 virulence factor TspB C-terminal domain-related protein -
LP097_RS00770 (LP097_00770) 139771..140028 - 258 WP_112741693.1 hypothetical protein -
LP097_RS00775 (LP097_00775) 140099..140476 + 378 WP_264684286.1 hypothetical protein -
LP097_RS00780 (LP097_00780) 140599..140844 + 246 WP_078274709.1 hypothetical protein -
LP097_RS00785 (LP097_00785) 141131..141406 + 276 WP_078274708.1 hypothetical protein -
LP097_RS00790 (LP097_00790) 141401..141556 - 156 WP_158079680.1 hypothetical protein -
LP097_RS00795 141608..141742 - 135 WP_264676041.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-84)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12636.69 Da        Isoelectric Point: 10.0972

>T226201 WP_228157738.1 NZ_CP087803:c136803-136468 [Moraxella bovis]
MLHFAETSLFTKQIIDLMDDDEYRLLQTNLMKNPHQGDIVRGTGGVRKTRWSIDGKGKSGGSRIIYFFVDGAGIFFMLLA
YPKSKQTTLSADEKKEMLKLTTAIKEIYRAK

Download         Length: 336 bp

>T226201 NZ_CP122318:c837921-837547 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10425.98 Da        Isoelectric Point: 10.0023

>AT226201 WP_078274722.1 NZ_CP087803:c136478-136197 [Moraxella bovis]
VQNEFYDDLKASLTEALAIAKGEISPSRTFTYERPNIKDIRAKTGLSQTQFAQKLHISPKTLKNWEQGIRTPTGPAITLI
RLLDKNPDLISMA

Download         Length: 282 bp

>AT226201 NZ_CP122318:c838378-838010 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References