Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1784018..1784616 Replicon chromosome
Accession NZ_CP087800
Organism Moraxella bovis strain SAM57953

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LP087_RS08860 Protein ID WP_078275306.1
Coordinates 1784018..1784296 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag LP087_RS08865 Protein ID WP_078275307.1
Coordinates 1784311..1784616 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP087_RS08855 (LP087_08765) 1783348..1783932 - 585 WP_264676215.1 tail assembly protein -
LP087_RS08860 (LP087_08770) 1784018..1784296 + 279 WP_078275306.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LP087_RS08865 (LP087_08775) 1784311..1784616 + 306 WP_078275307.1 HigA family addiction module antitoxin Antitoxin
LP087_RS08870 (LP087_08780) 1784588..1785364 - 777 WP_078275308.1 C40 family peptidase -
LP087_RS08875 (LP087_08785) 1785432..1785620 - 189 WP_078275309.1 hypothetical protein -
LP087_RS08880 (LP087_08790) 1785617..1786213 - 597 WP_264676214.1 antA/AntB antirepressor family protein -
LP087_RS08885 (LP087_08795) 1786386..1786616 + 231 WP_078275311.1 Arc family DNA-binding protein -
LP087_RS08890 (LP087_08800) 1786658..1787341 - 684 WP_264676213.1 phage minor tail protein L -
LP087_RS08895 (LP087_08805) 1787338..1787727 - 390 WP_078275313.1 hypothetical protein -
LP087_RS08900 (LP087_08810) 1787763..1788095 - 333 WP_078275314.1 phage tail protein -
LP087_RS08905 (LP087_08815) 1788248..1789027 - 780 WP_264717799.1 tape measure protein -
LP087_RS08910 (LP087_08820) 1789406..1789606 + 201 WP_062501372.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1774982..1859379 84397


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-95)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10491.92 Da        Isoelectric Point: 5.0474

>T226196 WP_078275306.1 NZ_CP087800:1784018-1784296 [Moraxella bovis]
MIQSFKCKDAQSLFETGSSRVFANFLSVATRKLTMLDNAVALADLRIPPANRLEKLTGDREGQYSIRINDQFRICFVWGD
DGVYDVEIVDYH

Download         Length: 279 bp

>T226196 NZ_CP122318:4521-4856 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11173.81 Da        Isoelectric Point: 7.3174

>AT226196 WP_078275307.1 NZ_CP087800:1784311-1784616 [Moraxella bovis]
MFKNGMRPVHAGEVLREEYLIPMGMSATALANALGVTPARINDIVRQRRGVTADTALRLARYFGGTAQFWLNLQTTYELR
LAETTLGDSLDFISPHEVAHA

Download         Length: 306 bp

>AT226196 NZ_CP122318:4273-4521 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References