Detailed information of TA system TA226189

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 101049..101655
• Replicon: chromosome
• Accession: NZ_CP087800
• Organism: Moraxella bovis strain SAM57953

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: LP087_RS00495
• Protein ID: WP_228157738.1
• Coordinates: 101320..101655 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: LP087_RS00490
• Protein ID: WP_078274722.1
• Coordinates: 101049..101330 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP087_RS00465 (LP087_00470)	96747..97505	+	759	WP_078274726.1	YciK family oxidoreductase	-
LP087_RS00470 (LP087_00475)	97615..98940	+	1326	WP_112741690.1	hemolysin family protein	-
LP087_RS00475 (LP087_00480)	99085..99807	+	723	WP_029103568.1	nitroreductase family protein	-
LP087_RS00480 (LP087_00485)	99847..100059	-	213	WP_078274724.1	hypothetical protein	-
LP087_RS00485 (LP087_00490)	100175..100999	-	825	WP_078274723.1	site-specific integrase	-
LP087_RS00490 (LP087_00495)	101049..101330	-	282	WP_078274722.1	NadS family protein	Antitoxin
LP087_RS00495 (LP087_00500)	101320..101655	-	336	WP_228157738.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LP087_RS00500 (LP087_00505)	101719..102879	-	1161	WP_078274721.1	zonular occludens toxin domain-containing protein	-
LP087_RS00505 (LP087_00510)	102965..103258	-	294	WP_078274720.1	DUF2523 family protein	-
LP087_RS00510 (LP087_00515)	103255..104130	-	876	WP_162860331.1	virulence factor TspB C-terminal domain-related protein	-
LP087_RS00515 (LP087_00520)	104713..104880	-	168	WP_264717823.1	hypothetical protein	-
LP087_RS00520 (LP087_00525)	104999..105328	+	330	WP_264676042.1	hypothetical protein	-
LP087_RS00525 (LP087_00530)	105451..105696	+	246	WP_078274709.1	hypothetical protein	-
LP087_RS00530 (LP087_00535)	105983..106258	+	276	WP_078274708.1	hypothetical protein	-
LP087_RS00535 (LP087_00540)	106253..106408	-	156	WP_158079680.1	hypothetical protein	-
LP087_RS00540	106460..106594	-	135	WP_264676041.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (43-106)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-84)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 12636.69 Da
• Isoelectric Point: 10.0972

>T226189 WP_228157738.1 NZ_CP087800:c101655-101320 [Moraxella bovis]
MLHFAETSLFTKQIIDLMDDDEYRLLQTNLMKNPHQGDIVRGTGGVRKTRWSIDGKGKSGGSRIIYFFVDGAGIFFMLLA
YPKSKQTTLSADEKKEMLKLTTAIKEIYRAK

Nucleotide

• Length: 336 bp

>T226189 NZ_CP122317:3786383-3786724 [Escherichia coli]
ATGAAAACTTTACCTGCAATAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10425.98 Da
• Isoelectric Point: 10.0023

>AT226189 WP_078274722.1 NZ_CP087800:c101330-101049 [Moraxella bovis]
VQNEFYDDLKASLTEALAIAKGEISPSRTFTYERPNIKDIRAKTGLSQTQFAQKLHISPKTLKNWEQGIRTPTGPAITLI
RLLDKNPDLISMA

Nucleotide

• Length: 282 bp

>AT226189 NZ_CP122317:3786045-3786362 [Escherichia coli]
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCTCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA