Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1861705..1862303 Replicon chromosome
Accession NZ_CP087798
Organism Moraxella bovis strain SAM57954

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LP098_RS09285 Protein ID WP_078275306.1
Coordinates 1861705..1861983 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag LP098_RS09290 Protein ID WP_078275307.1
Coordinates 1861998..1862303 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP098_RS09280 (LP098_09180) 1861035..1861619 - 585 WP_264676215.1 tail assembly protein -
LP098_RS09285 (LP098_09185) 1861705..1861983 + 279 WP_078275306.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LP098_RS09290 (LP098_09190) 1861998..1862303 + 306 WP_078275307.1 HigA family addiction module antitoxin Antitoxin
LP098_RS09295 (LP098_09195) 1862275..1863051 - 777 WP_078275308.1 C40 family peptidase -
LP098_RS09300 (LP098_09200) 1863119..1863307 - 189 WP_078275309.1 hypothetical protein -
LP098_RS09305 (LP098_09205) 1863304..1863900 - 597 WP_264676214.1 antA/AntB antirepressor family protein -
LP098_RS09310 (LP098_09210) 1864073..1864303 + 231 WP_078275311.1 Arc family DNA-binding protein -
LP098_RS09315 (LP098_09215) 1864345..1865028 - 684 WP_264676213.1 phage minor tail protein L -
LP098_RS09320 (LP098_09220) 1865025..1865414 - 390 WP_078275313.1 hypothetical protein -
LP098_RS09325 (LP098_09225) 1865450..1865782 - 333 WP_078275314.1 phage tail protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1846291..1901467 55176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-95)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10491.92 Da        Isoelectric Point: 5.0474

>T226185 WP_078275306.1 NZ_CP087798:1861705-1861983 [Moraxella bovis]
MIQSFKCKDAQSLFETGSSRVFANFLSVATRKLTMLDNAVALADLRIPPANRLEKLTGDREGQYSIRINDQFRICFVWGD
DGVYDVEIVDYH

Download         Length: 279 bp

>T226185 NZ_CP122317:3109044-3109385 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11173.81 Da        Isoelectric Point: 7.3174

>AT226185 WP_078275307.1 NZ_CP087798:1861998-1862303 [Moraxella bovis]
MFKNGMRPVHAGEVLREEYLIPMGMSATALANALGVTPARINDIVRQRRGVTADTALRLARYFGGTAQFWLNLQTTYELR
LAETTLGDSLDFISPHEVAHA

Download         Length: 306 bp

>AT226185 NZ_CP122317:c3109049-3108973 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References