Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 1861705..1862303 | Replicon | chromosome |
| Accession | NZ_CP087798 | ||
| Organism | Moraxella bovis strain SAM57954 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | LP098_RS09285 | Protein ID | WP_078275306.1 |
| Coordinates | 1861705..1861983 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | graA | Uniprot ID | - |
| Locus tag | LP098_RS09290 | Protein ID | WP_078275307.1 |
| Coordinates | 1861998..1862303 (+) | Length | 102 a.a. |
Genomic Context
Location: 1861705..1861983 (279 bp)
Type: Toxin
Protein ID: WP_078275306.1
Type: Toxin
Protein ID: WP_078275306.1
Location: 1861998..1862303 (306 bp)
Type: Antitoxin
Protein ID: WP_078275307.1
Type: Antitoxin
Protein ID: WP_078275307.1
Location: 1864073..1864303 (231 bp)
Type: Others
Protein ID: WP_078275311.1
Type: Others
Protein ID: WP_078275311.1
Location: 1861035..1861619 (585 bp)
Type: Others
Protein ID: WP_264676215.1
Type: Others
Protein ID: WP_264676215.1
Location: 1862275..1863051 (777 bp)
Type: Others
Protein ID: WP_078275308.1
Type: Others
Protein ID: WP_078275308.1
Location: 1863119..1863307 (189 bp)
Type: Others
Protein ID: WP_078275309.1
Type: Others
Protein ID: WP_078275309.1
Location: 1863304..1863900 (597 bp)
Type: Others
Protein ID: WP_264676214.1
Type: Others
Protein ID: WP_264676214.1
Location: 1864345..1865028 (684 bp)
Type: Others
Protein ID: WP_264676213.1
Type: Others
Protein ID: WP_264676213.1
Location: 1865025..1865414 (390 bp)
Type: Others
Protein ID: WP_078275313.1
Type: Others
Protein ID: WP_078275313.1
Location: 1865450..1865782 (333 bp)
Type: Others
Protein ID: WP_078275314.1
Type: Others
Protein ID: WP_078275314.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LP098_RS09280 (LP098_09180) | 1861035..1861619 | - | 585 | WP_264676215.1 | tail assembly protein | - |
| LP098_RS09285 (LP098_09185) | 1861705..1861983 | + | 279 | WP_078275306.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LP098_RS09290 (LP098_09190) | 1861998..1862303 | + | 306 | WP_078275307.1 | HigA family addiction module antitoxin | Antitoxin |
| LP098_RS09295 (LP098_09195) | 1862275..1863051 | - | 777 | WP_078275308.1 | C40 family peptidase | - |
| LP098_RS09300 (LP098_09200) | 1863119..1863307 | - | 189 | WP_078275309.1 | hypothetical protein | - |
| LP098_RS09305 (LP098_09205) | 1863304..1863900 | - | 597 | WP_264676214.1 | antA/AntB antirepressor family protein | - |
| LP098_RS09310 (LP098_09210) | 1864073..1864303 | + | 231 | WP_078275311.1 | Arc family DNA-binding protein | - |
| LP098_RS09315 (LP098_09215) | 1864345..1865028 | - | 684 | WP_264676213.1 | phage minor tail protein L | - |
| LP098_RS09320 (LP098_09220) | 1865025..1865414 | - | 390 | WP_078275313.1 | hypothetical protein | - |
| LP098_RS09325 (LP098_09225) | 1865450..1865782 | - | 333 | WP_078275314.1 | phage tail protein | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1846291..1901467 | 55176 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10491.92 Da Isoelectric Point: 5.0474
>T226185 WP_078275306.1 NZ_CP087798:1861705-1861983 [Moraxella bovis]
MIQSFKCKDAQSLFETGSSRVFANFLSVATRKLTMLDNAVALADLRIPPANRLEKLTGDREGQYSIRINDQFRICFVWGD
DGVYDVEIVDYH
MIQSFKCKDAQSLFETGSSRVFANFLSVATRKLTMLDNAVALADLRIPPANRLEKLTGDREGQYSIRINDQFRICFVWGD
DGVYDVEIVDYH
Download Length: 279 bp
>T226185 NZ_CP122317:3109044-3109385 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA
Antitoxin
Download Length: 102 a.a. Molecular weight: 11173.81 Da Isoelectric Point: 7.3174
>AT226185 WP_078275307.1 NZ_CP087798:1861998-1862303 [Moraxella bovis]
MFKNGMRPVHAGEVLREEYLIPMGMSATALANALGVTPARINDIVRQRRGVTADTALRLARYFGGTAQFWLNLQTTYELR
LAETTLGDSLDFISPHEVAHA
MFKNGMRPVHAGEVLREEYLIPMGMSATALANALGVTPARINDIVRQRRGVTADTALRLARYFGGTAQFWLNLQTTYELR
LAETTLGDSLDFISPHEVAHA
Download Length: 306 bp
>AT226185 NZ_CP122317:c3109049-3108973 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT