Detailed information of TA system TA226169

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 2622066..2622672
• Replicon: chromosome
• Accession: NZ_CP087793
• Organism: Moraxella bovis strain SAM57959

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: LP112_RS13420
• Protein ID: WP_228157738.1
• Coordinates: 2622066..2622401 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: LP112_RS13425
• Protein ID: WP_078274722.1
• Coordinates: 2622391..2622672 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP112_RS13375	2617127..2617261	+	135	WP_264676041.1	hypothetical protein	-
LP112_RS13380 (LP112_13260)	2617313..2617468	+	156	WP_158079680.1	hypothetical protein	-
LP112_RS13385 (LP112_13265)	2617463..2617738	-	276	WP_078274708.1	hypothetical protein	-
LP112_RS13390 (LP112_13270)	2618025..2618270	-	246	WP_078274709.1	hypothetical protein	-
LP112_RS13395 (LP112_13275)	2618393..2618722	-	330	WP_264676042.1	hypothetical protein	-
LP112_RS13400 (LP112_13280)	2618841..2619098	+	258	WP_112741693.1	hypothetical protein	-
LP112_RS13405 (LP112_13285)	2619591..2620466	+	876	WP_162860331.1	virulence factor TspB C-terminal domain-related protein	-
LP112_RS13410 (LP112_13290)	2620463..2620756	+	294	WP_078274720.1	DUF2523 family protein	-
LP112_RS13415 (LP112_13295)	2620842..2622002	+	1161	WP_078274721.1	zonular occludens toxin domain-containing protein	-
LP112_RS13420 (LP112_13300)	2622066..2622401	+	336	WP_228157738.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LP112_RS13425 (LP112_13305)	2622391..2622672	+	282	WP_078274722.1	NadS family protein	Antitoxin
LP112_RS13430 (LP112_13310)	2622722..2623546	+	825	WP_078274723.1	site-specific integrase	-
LP112_RS13435 (LP112_13315)	2623662..2623874	+	213	WP_078274724.1	hypothetical protein	-
LP112_RS13440 (LP112_13320)	2623914..2624636	-	723	WP_029103568.1	nitroreductase family protein	-
LP112_RS13445 (LP112_13325)	2624781..2626106	-	1326	WP_112741690.1	hemolysin family protein	-
LP112_RS13450 (LP112_13330)	2626216..2626974	-	759	WP_078274726.1	YciK family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (43-106)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-84)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 12636.69 Da
• Isoelectric Point: 10.0972

>T226169 WP_228157738.1 NZ_CP087793:2622066-2622401 [Moraxella bovis]
MLHFAETSLFTKQIIDLMDDDEYRLLQTNLMKNPHQGDIVRGTGGVRKTRWSIDGKGKSGGSRIIYFFVDGAGIFFMLLA
YPKSKQTTLSADEKKEMLKLTTAIKEIYRAK

Nucleotide

• Length: 336 bp

>T226169 NZ_CP122316:4577200-4577535 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10425.98 Da
• Isoelectric Point: 10.0023

>AT226169 WP_078274722.1 NZ_CP087793:2622391-2622672 [Moraxella bovis]
VQNEFYDDLKASLTEALAIAKGEISPSRTFTYERPNIKDIRAKTGLSQTQFAQKLHISPKTLKNWEQGIRTPTGPAITLI
RLLDKNPDLISMA

Nucleotide

• Length: 282 bp

>AT226169 NZ_CP122316:4576952-4577200 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA