Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 920075..920673 Replicon chromosome
Accession NZ_CP087793
Organism Moraxella bovis strain SAM57959

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LP112_RS04895 Protein ID WP_078275306.1
Coordinates 920395..920673 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag LP112_RS04890 Protein ID WP_078275307.1
Coordinates 920075..920380 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP112_RS04855 (LP112_04835) 916596..916928 + 333 WP_078275314.1 phage tail protein -
LP112_RS04860 (LP112_04840) 916964..917353 + 390 WP_078275313.1 hypothetical protein -
LP112_RS04865 (LP112_04845) 917350..918033 + 684 WP_264676213.1 phage minor tail protein L -
LP112_RS04870 (LP112_04850) 918075..918305 - 231 WP_078275311.1 Arc family DNA-binding protein -
LP112_RS04875 (LP112_04855) 918478..919074 + 597 WP_264676214.1 antA/AntB antirepressor family protein -
LP112_RS04880 (LP112_04860) 919071..919259 + 189 WP_078275309.1 hypothetical protein -
LP112_RS04885 (LP112_04865) 919327..920103 + 777 WP_078275308.1 C40 family peptidase -
LP112_RS04890 (LP112_04870) 920075..920380 - 306 WP_078275307.1 HigA family addiction module antitoxin Antitoxin
LP112_RS04895 (LP112_04875) 920395..920673 - 279 WP_078275306.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LP112_RS04900 (LP112_04880) 920759..921343 + 585 WP_264676215.1 tail assembly protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 883346..929709 46363


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-95)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10491.92 Da        Isoelectric Point: 5.0474

>T226162 WP_078275306.1 NZ_CP087793:c920673-920395 [Moraxella bovis]
MIQSFKCKDAQSLFETGSSRVFANFLSVATRKLTMLDNAVALADLRIPPANRLEKLTGDREGQYSIRINDQFRICFVWGD
DGVYDVEIVDYH

Download         Length: 279 bp

>T226162 NZ_CP122316:c2864073-2863816 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11173.81 Da        Isoelectric Point: 7.3174

>AT226162 WP_078275307.1 NZ_CP087793:c920380-920075 [Moraxella bovis]
MFKNGMRPVHAGEVLREEYLIPMGMSATALANALGVTPARINDIVRQRRGVTADTALRLARYFGGTAQFWLNLQTTYELR
LAETTLGDSLDFISPHEVAHA

Download         Length: 306 bp

>AT226162 NZ_CP122316:c2863804-2863259 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References